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UA Study’s Findings Key to Understanding Immunity as We Age

By Guest PostJanuary 11, 2014Healthaging, arizona center, as we age, cd8 t cells, effective immune response, elizabeth bowman, gang li, intracellular bacteria, intracellular pathogens, janko nikolich zugich, key, kristin r renkema, malaria, megan j smithey, new infections, parasites, t cell receptor, t cells, tcr, ua study, understanding immunity, virtual memory, virus infected cells, viruses, white blood cells

UA researchers have discovered that two separate defects combine to contribute to reduced T cell responses with aging.

Researchers at the University of Arizona College of Medicine – Tucson have found a key to understanding the aging immune system’s decreased response to infectious diseases, which remain among the leading causes of death in older adults.

Aging profoundly affects the immune system’s T cells – the types of white blood cells that defend against intracellular pathogens, such as viruses, intracellular bacteria or parasites, such as malaria. Newly encountered pathogens are attacked by what are known as naïve T cells, some of which then learn and remember, becoming memory T cells that prevent reinfection when they encounter the same pathogen again. But naïve T cells become depleted with age, leading to less effective immune responses against new infections. (more…)

Multiple Sclerosis Study Reveals How Killer T Cells Learn to Recognize Nerve Fiber Insulators

By Guest PostJanuary 12, 2013Healtharsenal, autoimmune disorders, autoimmune encephalitis, autoimmune reactivity, axons, blood vessels, body, brain, branched tentacles, cancer, cd4+ t cell, cd8 t cells, central nervous system, chronic multiple sclerosis, corticosteroids, cytoxic t cells, degeneration of axons, electrical impulse conductors, electrical wire, fight disease, generalized immunosuppressants, humans, infection, inflamed lesions, inflammatory response, inflammatory situation, insulation, joan goverman, killer t cells, laboratory models, lesions, luca castelli, methotrexate, mouse model, multiple sclerosis, myelin protein, myelin sheath, nerve cell projections, nerve fibers, no cells, oligodendrocytes, pathogens, peptides, proteins, qingyong ji, spines, support cells, symptoms, tip dendritic cells, tissue damage, transmit signals, university of washington, white blood cells

Misguided killer T cells may be the missing link in sustained tissue damage in the brains and spines of people with multiple sclerosis, findings from the University of Washington reveal. Cytoxic T cells, also known as CD8+ T cells, are white blood cells that normally are in the body’s arsenal to fight disease.

Multiple sclerosis is characterized by inflamed lesions that damage the insulation surrounding nerve fibers and destroy the axons, electrical impulse conductors that look like long, branching projections. Affected nerves fail to transmit signals effectively. (more…)

Researchers Discover Way to ‘Amp Up’ Power of Killer T Cells in Immune System

By Guest PostMay 22, 2011Health, Scienceanti tumor function, brain, cd8 cells, cd8 t cells, cytokines, dendritic cell vaccines, dominique lisiero, fight viruses, glioblastoma, il-12, imiquimod, immune system, interleukin-12, jonsson comprehensive cancer center, killer t cells, melanoma, models of metastatic melanoma, robert prins, tlrs, toll like receptors

Researchers at UCLA’s Jonsson Comprehensive Cancer Center have discovered a way to “amp up” the power of killer T cells known as CD8 cells in the immune system, making them more functional for longer periods of time and boosting their ability to multiply and expand within the body to fight melanoma.

The study, done in mouse models of metastatic melanoma that had spread to the brain, has important clinical implications, as the method could improve the cancer-killing power of experimental immunotherapies being tested now for various cancers, including deadly glioblastoma and metastatic melanoma, both of which are very difficult to treat successfully. (more…)

Tag Archives: cd8 t cells

UA Study’s Findings Key to Understanding Immunity as We Age

Multiple Sclerosis Study Reveals How Killer T Cells Learn to Recognize Nerve Fiber Insulators

Researchers Discover Way to ‘Amp Up’ Power of Killer T Cells in Immune System