As a human resources exec, Chuck Edward has long championed the voices of others and encouraged their stories. He has traveled globally, from India to Romania, with thoughtful advice for employees and job candidates to be vulnerable, open-minded and authentic. He’s a well-known, compassionate mentor who enjoys coaching people and shaping an inclusive culture that gives everyone “permission to be real.”(more…)
A study by UCLA researchers reveals the cellular basis for how the hormone estrogen protects against damage to the central nervous system in women with multiple sclerosis, or MS. The researchers found that estrogen treatment exerts positive effects on two types of cells during disease — immune cells in the brain as well as cells called oligodendrocytes.(more…)
Scientists have created a molecular map that pinpoints genetic variants that play a role in 21 different autoimmune diseases, they report Oct. 27 in the journal Nature.
Researchers at Yale, the University of California-San Francisco (UCSF), and the Broad Institute of MIT and Harvard developed a sophisticated mathematical model and created maps of different cell types that together enabled them to identify which variants cause the immune response to go awry and cause specific diseases. (more…)
In the past decade, scientists have identified a handful of genes connected with Parkinson’s disease. Now, a team of UCLA researchers has identified another gene involved in the neurological disorder. Their finding may provide a target for drugs that could one day prevent or even cure the debilitating illness. (more…)
Study identifies essential molecule for transport of protein from neuron cell body to axon
COLUMBUS, Ohio – Scientists have solved a longstanding mystery of the central nervous system, showing how a key protein gets to the right spot to launch electrical impulses that enable communication of nerve signals to and from the brain. Nerve impulses are critical because they are required for neurons to send information about senses, movement, thinking and feeling to other cell types in the neural circuitry. And an impulse is not fired up just once; it is initiated and then must be repeatedly transmitted along axons – long, slender extensions of nerve cell bodies – to keep the nervous system’s messages stable during their rapid travel. (more…)
Eleven regions of the human genome have been newly discovered to influence the onset of Alzheimer’s disease. The findings stem from the largest international study ever conducted on this disorder, which causes gradual memory loss and other forms of cognitive decline in older people.
As of 2009, 10 genes were known to be related to Alzheimer’s, the result of about a quarter-century of research. Yet the reasons behind individual susceptibility or resistance to the disease continued to be poorly understood. In February of 2011, four international research groups studying Alzheimer’s disease genetics united to more quickly identify other genes related to the disorder. (more…)
For the past few decades, health officials have been reporting increases in the incidence of autoimmune diseases such as multiple sclerosis (MS). Now researchers at Yale Medical School, Harvard Medical School and the Broad Institute have identified a prime suspect in the mystery — dietary salt.
In the March 6 issue of the journal Nature, Yale researchers showed that salt can induce and worsen pathogenic immune system responses in mice and that the response is regulated by genes already implicated in a variety of autoimmune diseases. (more…)
UCLA researchers, in a finding that runs counter to conventional wisdom, have discovered for the first time that a gene thought to express a stress-response protein in all cells that come under stress instead expresses the protein only in specific cell types.
The research team, from the Jules Stein Eye Institute at UCLA and the UCLA Division of Pulmonary and Critical Care Medicine, focused on αB-Crystallin, one of a class of molecules known as heat shock proteins, which are involved in the folding and unfolding of other proteins, helping them recover from stress so they can do their job. (more…)
