david hafler – Shamskm: A site to exchange knowledge and solutions

Molecular map reveals genetic origins of 21 autoimmune diseases

Scientists have created a molecular map that pinpoints genetic variants that play a role in 21 different autoimmune diseases, they report Oct. 27 in the journal Nature.

Researchers at Yale, the University of California-San Francisco (UCSF), and the Broad Institute of MIT and Harvard developed a sophisticated mathematical model and created maps of different cell types that together enabled them to identify which variants cause the immune response to go awry and cause specific diseases. (more…)

Yale Researchers Identify Salt as a Trigger of Autoimmune Diseases

By Guest PostMarch 14, 2013Healthautoimmune diseases, autoimmune encephalomyelitis, aviv regev, david hafler, destructive immune system, dietary salt, disease, dominik mueller, Environment, function, gene, Germany, hallmark of autoimmunity, high salt content, hypertension, immune cell, low fat diet, low salt, molecular circuitry, ms, multiple sclerosis, mystery, Nature, pathogenic th17 cells, prime suspect, sub-saharan africa, t helper 17, th17 cell, vijay kuchroo

For the past few decades, health officials have been reporting increases in the incidence of autoimmune diseases such as multiple sclerosis (MS). Now researchers at Yale Medical School, Harvard Medical School and the Broad Institute have identified a prime suspect in the mystery — dietary salt.

In the March 6 issue of the journal Nature, Yale researchers showed that salt can induce and worsen pathogenic immune system responses in mice and that the response is regulated by genes already implicated in a variety of autoimmune diseases. (more…)

Tag Archives: david hafler

Molecular map reveals genetic origins of 21 autoimmune diseases

Yale Researchers Identify Salt as a Trigger of Autoimmune Diseases