Sometimes the cure can be worse than the disease. Pharmaceutical drugs are known for their potential side effects, and an important aspect of personalized medicine is to tailor therapies to individuals to reduce the chances of adverse events. Now researchers from North Carolina State University have updated an extensive toxicology database so that it can be used to track information about therapeutic drugs and their unintentional toxic effects.
“Environmental science actually shares a common goal with drug makers: to improve the prediction of chemical toxicity,” says Dr. Allan Peter Davis, lead author of a paper on the work and the biocuration project manager of the Comparative Toxicogenomics Database (CTD) in NC State’s Department of Biological Sciences. (more…)
Research shows a correlation between eating breakfast and a reduced risk of type 2 diabetes
As Americans continue to fight the obesity epidemic and try to stem the incidence of type 2 diabetes, dietary guidelines are becoming increasingly important.
Among the possible keys to better health? Eating breakfast, for starters. (more…)
For the past few decades, health officials have been reporting increases in the incidence of autoimmune diseases such as multiple sclerosis (MS). Now researchers at Yale Medical School, Harvard Medical School and the Broad Institute have identified a prime suspect in the mystery — dietary salt.
In the March 6 issue of the journal Nature, Yale researchers showed that salt can induce and worsen pathogenic immune system responses in mice and that the response is regulated by genes already implicated in a variety of autoimmune diseases. (more…)
Most people today look at diet plans to help them lose weight; however, these plans can also serve other purposes such as keeping heart disease and diabetes at bay. With all the different diet plans on offer, choosing the one that is right for you can be a tough job. Take a look at these plans that were evaluated by health experts and received high rankings in a recent survey by U.S. News, and make your decision.
The Mediterranean Diet
Like the Mayo Clinic Diet, the Mediterranean Diet plan helps to achieve and maintain a healthy weight and also prevent or control diabetes, brain and heart disorders and even cancer. Drawing inspiration from the diet of people in the European countries around the Mediterranean Sea, this diet focuses on eating more of nuts, herbs and spices, whole grains, vegetables and fruits, seafood and fish, and cutting down on red meat, saturated fat foods and sugar. With its emphasis on mono- and polyunsaturated fats and avoidance of saturated fat, this diet is effective at reducing bad cholesterol and keeping blood pressure low. Although it is one of the top diet programs, the only possible weakness lies in the fact that the plan is not a structured one and so, the onus lies on you to come up with a calorie chart to follow. (more…)
TORONTO, ON – Elderly people taking anti-hypertensive drugs are at a 43 per cent increased risk of having a hip fracture in the first 45 days of treatment, according to research conducted by family medicine Assistant Professor Dr. Debra Butt. A member of the Department of Family and Community Medicine at the University of Toronto and a family physician affiliated with The Scarborough Hospital, Dr. Butt’s study was published on November 19, 2012 in Archives of Internal Medicine. The study examined data from health care administrative databases in Ontario, looking at records from 2000 to 2009 for community-dwelling hypertensive patients with a mean age of 80.8 years.
There are serious consequences to a hip fracture for the elderly. In the first year of a hip fracture there is a higher mortality rate than is seen for many chronic diseases. Those who recover often lose their independence due to reduced mobility, which can result in depression and overall decreased quality of life. (more…)
Playing football (soccer) could be the best way for people with high blood pressure, known as hypertension, to improve their fitness, normalise their blood pressure and reduce their risk of stroke, according to research published today (Monday 15 October 2012) in the journal Medicine and Science in Sports and Exercise.
Research from Universities of Exeter and Copenhagen, and Gentofte University Hospital in Denmark suggests football training prevents cardiovascular disease in middle-aged men with hypertension and is more effective than healthy lifestyle advice currently prescribed by GPs.
After six months of football training, three out of four men in this study had blood pressure within the normal, healthy range. (more…)
EAST LANSING, Mich. — A receptor found on blood platelets whose importance as a potential pharmaceutical target has long been questioned may in fact be fruitful in drug testing, according to new research from Michigan State University chemists.
A team led by Dana Spence of MSU’s Department of Chemistry has revealed a way to isolate and test the receptor known as P2X1. By creating a new, simple method to study it after blood is drawn, the team has unlocked a potential new drug target for many diseases that impact red blood cells, such as diabetes, hypertension and cystic fibrosis. (more…)
Yale School of Medicine researchers have discovered that a variant of a gene linked to heart disease also increases the risk of deadly aneurysms of blood vessels in the brain. The discovery of this link raises hopes for new treatments for intracranial aneurysms, which affect more than a half million people worldwide annually.
“Existing drugs already target this common pathway and, in the future, could help treat or prevent aneurysms in people who are at risk,” said Murat Gunel, professor of neurosurgery, genetics and neurobiology and senior author of the study, published the week of Nov. 21 in the Proceedings of the National Academy of Sciences. (more…)
