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Database Tracks Toxic Side Effects of Pharmaceuticals

By Guest PostDecember 22, 2013Environment, Healthahmed enayetallah, allan peter davis, chemical toxicity, comparative toxicogenomics database, ctd, daniela sciaky, database, environmental science, gene testing patients, hypertension, jean lay, kelley lennon hopkins, kidney failure, liver disease, north Carolina, novel prediction, pfizer, pharmaceuticals, phenotype module, prediction, project, seizures, state university, thomas wiegers, toxic endpoints, toxic side effects

Sometimes the cure can be worse than the disease. Pharmaceutical drugs are known for their potential side effects, and an important aspect of personalized medicine is to tailor therapies to individuals to reduce the chances of adverse events. Now researchers from North Carolina State University have updated an extensive toxicology database so that it can be used to track information about therapeutic drugs and their unintentional toxic effects.

“Environmental science actually shares a common goal with drug makers: to improve the prediction of chemical toxicity,” says Dr. Allan Peter Davis, lead author of a paper on the work and the biocuration project manager of the Comparative Toxicogenomics Database (CTD) in NC State’s Department of Biological Sciences. (more…)

New device could cut costs on household products, pharmaceuticals

By Guest PostMay 13, 2013Sciencealice dohnalkova, amy shen, cost, flow of liquid, flow procedure, fluid, household products, joshua cardiel, microfluidics, micron level, microscopic channels, nanoscale packages, neville dubash, pharmaceuticals, pump water, soap products, toxic, university of washington, web, ya zhao

Sometimes cost saving comes in nanoscale packages.

A new procedure that thickens and thins fluid at the micron level could save consumers and manufacturers money, particularly for soap products that depend on certain molecules to effectively deal with grease and dirt. Researchers at the University of Washington published their findings online April 9 in the Proceedings of the National Academy of Sciences.

Read the back of most shampoos and dishwashing detergents and you’ll find the word “surfactant” in the list of active ingredients. Surfactant molecules are tiny, yet they are the reason dish soap can attack an oily spot and shampoo can rid the scalp of grease. (more…)

Largest-Ever Map of Interactions of Plant Proteins Produced

By Guest PostJuly 31, 2011Scienceagriculture, arabidopsis, arabidopsis interactome mapping consortium, arabidopsis network map, arabidopsis thaliana, crop plants, interactome, joseph ecker, map of protein interactions, model organism for biological studies of plants, model plant, mustard plant, national science foundation, pharmaceuticals, plant growth and disease resistance, protein to protein, salk institute

*New map of protein interactions in model plant may help scientists improve plant species used in agriculture and pharmaceuticals*

An international consortium of scientists has produced the first systematic network map of interactions that occur between proteins in the plant Arabidopsis thaliana. (Arabidopsis is a mustard plant that has 27,000 proteins and serves as a popular model organism for biological studies of plants, analogous to lab rats that serve as popular model organisms for biological studies of animals.)

Known as an “interactome,” the new Arabidopsis network map defines 6,205 protein-to-protein Arabidopsis interactions involving 2,774 individual proteins. By itself, this map doubles the volume of data on protein interactions in plants that is currently available. (more…)

Tag Archives: pharmaceuticals

Database Tracks Toxic Side Effects of Pharmaceuticals

New device could cut costs on household products, pharmaceuticals

Largest-Ever Map of Interactions of Plant Proteins Produced