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Database Tracks Toxic Side Effects of Pharmaceuticals

By Guest PostDecember 22, 2013Environment, Healthahmed enayetallah, allan peter davis, chemical toxicity, comparative toxicogenomics database, ctd, daniela sciaky, database, environmental science, gene testing patients, hypertension, jean lay, kelley lennon hopkins, kidney failure, liver disease, north Carolina, novel prediction, pfizer, pharmaceuticals, phenotype module, prediction, project, seizures, state university, thomas wiegers, toxic endpoints, toxic side effects

Sometimes the cure can be worse than the disease. Pharmaceutical drugs are known for their potential side effects, and an important aspect of personalized medicine is to tailor therapies to individuals to reduce the chances of adverse events. Now researchers from North Carolina State University have updated an extensive toxicology database so that it can be used to track information about therapeutic drugs and their unintentional toxic effects.

“Environmental science actually shares a common goal with drug makers: to improve the prediction of chemical toxicity,” says Dr. Allan Peter Davis, lead author of a paper on the work and the biocuration project manager of the Comparative Toxicogenomics Database (CTD) in NC State’s Department of Biological Sciences. (more…)

Wearable Artificial Kidney to Be Tested For Safety and Effectiveness in Collaboration with FDA

By Guest PostApril 10, 2012Healthartificial kidney, dialysis community, kidney failure, kidney transplants, renal disease, wearable artificial kidney

A wearable artificial kidney, designed as a new treatment for kidney failure, will be tested in Seattle. The trial will be done in collaboration with the Food and Drug Administration under a new Innovations Pathway announced Monday. (more…)

Will This Be The End of Hamburger Disease?

By Guest PostNovember 28, 2010Health, Sciencebacteria, blood vessels, cow, dairy products, e coli, e coli bacterium, e coli o157:h7, ethanolamine, food contamination, food poisoning, hamburger disease, human infections, intestine, josée harel, kidney failure, meat, nitrogen, projectsafebeef, raw milk, red blood cells, veterinary medicine

E. coli bacteria. Image credit: University of Montreal

Hamburger disease, a debilitating form of food poisoning, may be a thing of the past. New findings from an international research collaboration conducted by the French National Institute for Agronomic Research (INRA), involving the Université de Montréal are the first to show how the contaminating E.coli bacterium is able to survive in the competitive environment of a cow’s intestine by scavenging specific food sources. Published in this month’s Environmental Microbiology, and featured in Nature Reviews Microbiology, this study may lead to non-medicinal methods for eradicating this invasive bug.

“We studied E.coli O157:H7, which is the most prevalent species of bacteria associated with larger outbreaks,” says Josée Harel, co-author of the study and director of the Groupe de Recherche sur les Maladies Infectieuses du Porc at the Université de Montréal’s Faculty of Veterinary Medicine. “These outbreaks have been associated with direct contact with the farm environment and with the consumption of meat, raw milk and dairy products. Reduction or eradication of O157:H7 in cows will lead to a substantial decrease in food contamination and consequential human infections.” (more…)

Tag Archives: kidney failure

Database Tracks Toxic Side Effects of Pharmaceuticals

Wearable Artificial Kidney to Be Tested For Safety and Effectiveness in Collaboration with FDA

Will This Be The End of Hamburger Disease?