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Chemists Unlock Potential Target For Drug Development

By Guest PostJanuary 22, 2012Scienceadditives, analytical methods, bleeding, blood flow, blood platelets, bloodstream, clotting, cystic fibrosis, dana spence, diabetes, diseases, drug testing, druggable receptors, enzymes, human body, hypertension, michigan state university, molecule, nf449, p2x1, p2y receptor, pharmaceutical target, platelets, receptor, red blood cells, sickle cell anemia

EAST LANSING, Mich. — A receptor found on blood platelets whose importance as a potential pharmaceutical target has long been questioned may in fact be fruitful in drug testing, according to new research from Michigan State University chemists.

A team led by Dana Spence of MSU’s Department of Chemistry has revealed a way to isolate and test the receptor known as P2X1. By creating a new, simple method to study it after blood is drawn, the team has unlocked a potential new drug target for many diseases that impact red blood cells, such as diabetes, hypertension and cystic fibrosis. (more…)

Replacing Body Parts Now More Than ‘Science Fiction’

If Dr. Laura Niklason has her way, vascular surgeons will someday be able to pull human veins off a shelf, whenever they want, to save lives.

Niklason is a pioneer in the science — and art — of tissue-engineered replacement of human body components. Last year, she led a research team that successfully implanted tissue-engineered lungs, cultured in vitro, in adult rats. For short intervals of time, the engineered lungs exchanged oxygen and carbon dioxide similarly to natural lungs. (more…)

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Chemists Unlock Potential Target For Drug Development

Replacing Body Parts Now More Than ‘Science Fiction’