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Lack of Protein Sp2 Disrupts Neuron Creation in Brain

By Guest PostJanuary 21, 2013Sciencecancer research, cell cycle regulator, cerebral cortex, creation of neurons, experimental mice, function of sp2, genetic tools, guanxi xiao, haifeng yin, how protein works, huixuan liang, jon horowitz, mechanism, neural therapies, neurodevelopmental diseases, north Carolina, offspring, program stem cell, protein, regeneration, regenerative medicine, simon hippenmeyer, skin, sp2, state university, stem cells, troy ghashghaei, tumor

A protein known as Sp2 is key to the proper creation of neurons from stem cells, according to researchers at North Carolina State University. Understanding how this protein works could enable scientists to “program” stem cells for regeneration, which has implications for neural therapies.

Troy Ghashghaei and Jon Horowitz, both faculty in NC State’s Department of Molecular Biomedical Sciences and researchers in the Center for Comparative Medicine and Translational Research, wanted to know more about the function of Sp2, a cell cycle regulator that helps control how cells divide. Previous research from Horowitz had shown that too much Sp2 in skin-producing stem cells resulted in tumors in experimental mice. Excessive amounts of Sp2 prevented the stem cells from creating normal cell “offspring,” or skin cells. Instead, the stem cells just kept producing more stem cells, which led to tumor formation. (more…)

UF Biologist Discovers Mammal with Salamander-like Regenerative Abilities

By Guest PostSeptember 29, 2012Natureafrican, african mammal, amphibian biology, ashley seifert, biopsy, blastema like, cartilage, damaged tissue, florida, hair follicles, human biology, ken muneoka, Kenya, lost limbs, model, mpala, nairobi, regenerative medicine, regrow, research, research centre, salamander, skin, skin autotomy, spiny mouse, structure, tissue regeneration, university, wound healing

GAINESVILLE, Fla. — A small African mammal with an unusual ability to regrow damaged tissues could inspire new research in regenerative medicine, a University of Florida study finds.

For years biologists have studied salamanders for their ability to regrow lost limbs. But amphibian biology is very different than human biology, so lessons learned in laboratories from salamanders are difficult to translate into medical therapies for humans. New research in the Sept. 27 issue of the journal Nature describes a mammal that can regrow new body tissues following an injury. The African spiny mouse could become a new model for research in regenerative medicine. (more…)

Radiation Generates Cancer Stem Cells From Less Aggressive Breast Cancer Cells

By Guest PostFebruary 19, 2012Healthbreast cancer, cancer cell, chemotherapy, dna damage, frank pajonk, ibcsc, induced pluripotent stem cells, ips, kim irwin, oncologist, radiation therapy, radiation treatment, regenerative medicine, stem cell, tumor, tumor recurrence

Breast cancer stem cells, thought to be the sole source of tumor recurrence, are known to be resistant to radiation therapy and don’t respond well to chemotherapy.

Now, researchers with the UCLA Department of Radiation Oncology at UCLA’s Jonsson Comprehensive Cancer Center report for the first time that radiation treatment, despite killing half of all tumor cells during every treatment, transforms other cancer cells into treatment-resistant breast cancer stem cells. (more…)

Replacing Body Parts Now More Than ‘Science Fiction’

By Guest PostFebruary 19, 2011Sciencecells, clinical trials, clotting, engineered lungs, genetically different cells, human body, human veins, infection, laura niklason, lunatic fringe, natural lungs, obstruction, regenerative medicine, science fiction, time of my life, tissue engineered lungs, tissue engineered replacement, vascular surgeons, vascular system

If Dr. Laura Niklason has her way, vascular surgeons will someday be able to pull human veins off a shelf, whenever they want, to save lives.

Niklason is a pioneer in the science — and art — of tissue-engineered replacement of human body components. Last year, she led a research team that successfully implanted tissue-engineered lungs, cultured in vitro, in adult rats. For short intervals of time, the engineered lungs exchanged oxygen and carbon dioxide similarly to natural lungs. (more…)

Tag Archives: regenerative medicine

Lack of Protein Sp2 Disrupts Neuron Creation in Brain

UF Biologist Discovers Mammal with Salamander-like Regenerative Abilities

Radiation Generates Cancer Stem Cells From Less Aggressive Breast Cancer Cells

Replacing Body Parts Now More Than ‘Science Fiction’