Tag Archives: cancer research

Leukaemia drug found to stimulate immunity against many cancer types

A class of drug currently being used to treat leukaemia has the unexpected side-effect of boosting immune responses against many different cancers, reports a new study led by scientists at UCL and the Babraham Institute, Cambridge.

The drugs, called p110δ inhibitors, have shown such remarkable efficacy against certain leukaemias in recent clinical trials that patients on the placebo were switched to the real drug. Until now, however, they have not been tested in other types of cancer. (more…)

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Lack of Protein Sp2 Disrupts Neuron Creation in Brain

A protein known as Sp2 is key to the proper creation of neurons from stem cells, according to researchers at North Carolina State University. Understanding how this protein works could enable scientists to “program” stem cells for regeneration, which has implications for neural therapies.

Troy Ghashghaei and Jon Horowitz, both faculty in NC State’s Department of Molecular Biomedical Sciences and researchers in the Center for Comparative Medicine and Translational Research, wanted to know more about the function of Sp2, a cell cycle regulator that helps control how cells divide. Previous research from Horowitz had shown that too much Sp2 in skin-producing stem cells resulted in tumors in experimental mice. Excessive amounts of Sp2 prevented the stem cells from creating normal cell “offspring,” or skin cells. Instead, the stem cells just kept producing more stem cells, which led to tumor formation. (more…)

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A Friend in the Fight against Cancer

The U is at the forefront of cancer research in dogs

After more than an hour discussing the shared evolution of dogs and humans, and how the cancer mysteries that lie deep within one may inform and effect treatments on the other, U researcher Jaime Modiano smiles and says, “I love my job.”

And why not?

He’s at the forefront of an array of exciting research that stands to improve the health of both dogs and people. (more…)

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