Tag Archives: tumor

Researchers find genes behind aggressive ovarian and endometrial cancers

In a major breakthrough for ovarian and uterine cancers, Yale researchers have defined the genetic landscape of rare, highly aggressive tumors called carcinosarcomas (CSs), pointing the way to possible new treatments. (more…)

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Wie Krebszellen gegen ihr Ableben kämpfen

Freiburger Forscher entschlüsseln Mechanismen, mit denen Tumore bei Stress ihr eigenes Wachstum fördern

Ein Enzym, das Tumorwachstum fördert, sammelt sich in gestressten Krebszellen verstärkt an. Das hat die Gruppe des Freiburger Molekularmediziners Prof. Dr. Thomas Reinheckel zusammen mit der Freiburger Biochemikerin Prof. Dr. Sabine Rospert sowie mit Prof. Dr. Elmar Stickeler und Dr. Peter Bronsert vom Universitätsklinikum Freiburg herausgefunden. Das Team hat die Forschungsergebnisse in der Fachzeitschrift „Journal of Biological Chemistry“ veröffentlicht.

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Winziger Sensor könnte Krebserkrankung schnell erkennen und überwachen – Prototyp geplant

Eine Erfindung aus Kassel könnte die Diagnostik von Krebserkrankungen und anderen Leiden vereinfachen, beschleunigen und kostengünstiger und exakter als bisherige Verfahren gestalten. Physiker und Biochemiker der Universität haben dafür eine neuartige Technikplattform entwickelt.

Diese Technikplattform kann mithilfe von „Fängermolekülen“ , einem durch Magnetfelder und magnetisierte kleinste Partikel gesteuerten Reinigungs- und Transportsystem sowie einem Sensor Indikatoren für das Vorhandensein eines bösartigen Tumors aus Blut oder Gewebeschnitten genau analysieren. Darauf haben die Wissenschaftler bereits ein europäisches Patent beantragt. (more…)

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Computer Simulation of Blood Vessel Growth

Early Step toward Treatment for Diseases that Affect Blood Flow

University of Utah bioengineers showed that tiny blood vessels grow better in the laboratory if the tissue surrounding them is less dense. Then the researchers created a computer simulation to predict such growth accurately – an early step toward treatments to provide blood supply to tissues damaged by diabetes and heart attacks and to skin grafts and implanted ligaments and tendons.

“Better understanding of the processes that regulate the growth of blood vessels puts us in a position ultimately to develop new treatments for diseases related to blood vessel growth,” and to better understand cancer metastasis, says bioengineering professor Jeff Weiss of the university’s Scientific Computing and Imaging Institute. (more…)

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New Look Inside Cell Nucleus Could Improve Cancer Diagnostics

Researchers have sequenced the entire messenger RNA – the “genetic photocopies” – contained in the nucleus of a single cell, a long-anticipated step toward better cancer diagnostics and other medical applications.

Researchers have successfully isolated and sequenced the entire messenger RNA – the “genetic photocopies” – contained in the nucleus of a single brain cell. This research, published in the journal Proceedings of the National Academy of Sciences, will help researchers better understand how organs function in health and disease and provide another stepping stone toward personalized medicine.   (more…)

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Lack of Protein Sp2 Disrupts Neuron Creation in Brain

A protein known as Sp2 is key to the proper creation of neurons from stem cells, according to researchers at North Carolina State University. Understanding how this protein works could enable scientists to “program” stem cells for regeneration, which has implications for neural therapies.

Troy Ghashghaei and Jon Horowitz, both faculty in NC State’s Department of Molecular Biomedical Sciences and researchers in the Center for Comparative Medicine and Translational Research, wanted to know more about the function of Sp2, a cell cycle regulator that helps control how cells divide. Previous research from Horowitz had shown that too much Sp2 in skin-producing stem cells resulted in tumors in experimental mice. Excessive amounts of Sp2 prevented the stem cells from creating normal cell “offspring,” or skin cells. Instead, the stem cells just kept producing more stem cells, which led to tumor formation. (more…)

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