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Computer Simulation of Blood Vessel Growth

By Guest PostJanuary 27, 2014Science3d computer simulation, angiogenesis, bioengineer, blood capillaries, blood vessel, blood vessel growth, blood vessel structure, capillaries, clayton underwood, collagen matrix, collagen matrix density, computer simulation, density, extracellular matrix, growth, heart, james guilkey, james hoying, jell o collagen, ligaments, lowell edgar, matrix, mechanical role, network, oxygen supply, oxygenated blood vessel, professor jeff weiss, stiffness, tendons, tissues damage, tumor, university of utah, vessel formation

Early Step toward Treatment for Diseases that Affect Blood Flow

University of Utah bioengineers showed that tiny blood vessels grow better in the laboratory if the tissue surrounding them is less dense. Then the researchers created a computer simulation to predict such growth accurately – an early step toward treatments to provide blood supply to tissues damaged by diabetes and heart attacks and to skin grafts and implanted ligaments and tendons.

“Better understanding of the processes that regulate the growth of blood vessels puts us in a position ultimately to develop new treatments for diseases related to blood vessel growth,” and to better understand cancer metastasis, says bioengineering professor Jeff Weiss of the university’s Scientific Computing and Imaging Institute. (more…)

Common Antifungal Drug Decreases Tumor Growth and Shows Promise as Cancer Therapy

By Guest PostAugust 21, 2012Health, Scienceangiogenesis, antifungal drug, austin, blood vessels, cancer therapy, cell, chemotherapy, edward marcotte, evolutionary relatedness, fibrosarcoma tumors, frogs, humans, hye ji cha, john wallingford, marcotte, mice, organism, petri dishes, thiabendazole, tumor growth, university of texas, vascular disrupting agent, vertebrate, yeast

AUSTIN, Texas — An inexpensive antifungal drug, thiabendazole, slows tumor growth and shows promise as a chemotherapy for cancer. Scientists in the College of Natural Sciences at The University of Texas at Austin made this discovery by exploiting the evolutionary relatedness of yeast, frogs, mice and humans.

Thiabendazole is an FDA-approved, generic drug taken orally that has been in clinical use for 40 years as an antifungal. It is not currently used for cancer therapy.

Hye Ji Cha, Edward Marcotte, John Wallingford and colleagues found that the drug destroys newly established blood vessels, making it a “vascular disrupting agent.” Their research was published in the journal PLoS Biology. (more…)

Breast Cancer Risk Varies Among Different Progestins Used in Hormone Replacement Therapy, MU Researchers Finds

By Guest PostAugust 11, 2010Healthangiogenesis, breast cancer, dmba-induced mammary tumors, estrogen, hormone replacement therapy, medroxporgresterone acetate, megestrol acetate, mga, mpa, n-el, n-one, norethindrone, norgesterel, progestins, salman hyder, sprague-dawley rats, synthetic progestin, tumor, tumors, uterine cancer, uterus, zalk endowed professor

COLUMBIA, Mo. – Progestins are used in hormone replacement therapies to counteract the negative effects of estrogen on the uterus and reduce the risk of uterine cancer.

However, evidence in recent studies and clinical trials has demonstrated that progestins increase the risk of breast cancer.

(more…)

Tag Archives: angiogenesis

Computer Simulation of Blood Vessel Growth

Common Antifungal Drug Decreases Tumor Growth and Shows Promise as Cancer Therapy

Breast Cancer Risk Varies Among Different Progestins Used in Hormone Replacement Therapy, MU Researchers Finds