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Fat cells in breast may connect social stress to breast cancer

By Guest PostJune 23, 2013Healthacaca, acetyl coa carboxykase, acly, aggressive breast cancer, antigen mice, atp citrate lyase, breast, carcinoma in situ, chronic stress, erin wonder, estrogen, fat cells, female mice, gene, her2, hexokinase, hk2, hormones, leptin, lumpectomy, mammary fat, mammary glands, martha mcclintock, matthew brady, maxwell skor, metabolism, metabolism of glucose, multiple tissues, paul volden, progesterone, receptor, social stress, suzanne conzen, sv40 t, triple negative, tumor growth, tumors, university of chicago

Local chemical signals released by fat cells in the mammary gland appear to provide a crucial link between exposure to unrelenting social stressors early in life, and the subsequent development of breast cancer, researchers from the University of Chicago report in the July 2013 issue of the journal Cancer Prevention Research.

Some forms of stress exposure may be associated with an increased risk of certain types of aggressive breast cancer. But the mechanisms linking the biology of social stress to cancer have been hard to identify. To unravel that mechanism, the researchers looked for differences between mice raised in small groups and those that grow up in an isolated setting—an established model of chronic stress without social supports. (more…)

Common Antifungal Drug Decreases Tumor Growth and Shows Promise as Cancer Therapy

By Guest PostAugust 21, 2012Health, Scienceangiogenesis, antifungal drug, austin, blood vessels, cancer therapy, cell, chemotherapy, edward marcotte, evolutionary relatedness, fibrosarcoma tumors, frogs, humans, hye ji cha, john wallingford, marcotte, mice, organism, petri dishes, thiabendazole, tumor growth, university of texas, vascular disrupting agent, vertebrate, yeast

AUSTIN, Texas — An inexpensive antifungal drug, thiabendazole, slows tumor growth and shows promise as a chemotherapy for cancer. Scientists in the College of Natural Sciences at The University of Texas at Austin made this discovery by exploiting the evolutionary relatedness of yeast, frogs, mice and humans.

Thiabendazole is an FDA-approved, generic drug taken orally that has been in clinical use for 40 years as an antifungal. It is not currently used for cancer therapy.

Hye Ji Cha, Edward Marcotte, John Wallingford and colleagues found that the drug destroys newly established blood vessels, making it a “vascular disrupting agent.” Their research was published in the journal PLoS Biology. (more…)

Yale Scientists Identify Gene That Controls The Spread of Melanoma

By Guest PostDecember 16, 2011Health, Sciencebeta catenin, braf gene, disease, drug treatments, gene, genetically altered mice, human melanoma, intestine, lungs, lymph nodes, malignant melanoma, manjula santhanakrishnan, marcus w bosenberg, melanoma, metastasis, skin, skin cancer, spleen, tumor growth, william damsky, yale cancer center

Yale Cancer Center researchers have identified a gene in melanoma that can dramatically affect the spread of the disease. The study, published in the journal Cancer Cell, provides new insight into how melanoma metastasizes in patients with advanced disease, and which organs are most likely to be affected. These findings could potentially lead to new drug treatments.

Malignant melanoma is the most deadly form of skin cancer, accounting for 80 percent of all skin cancer deaths. Nearly all melanoma deaths are a result of metastasis, which can occur early in the course of tumor growth in the skin. (more…)

UF Researchers Find Quiet Protein Speaks Loudly in Fight Against Cancer

By Guest PostMay 5, 2011Healthaubrey thompson, brahma, brm, cancer causing genes, cancer inhibiting properties, cancer therapy, carcinogens, cell adhesion, cells, david reisman, dna repair, geoffrey liu, hdac, histone deacetylase, lung cancer, oncogene, protein, race, sex, tumor growth, university of florida, university of toronto

GAINESVILLE, Fla. — When a movie character says, “It’s too quiet,” that’s usually a sign something bad may happen.

Now, University of Florida researchers have discovered that when variations of a certain protein in our cells are too quiet, it may add to the risk that someone will develop lung cancer. When scientists restored the protein to its normal, active self, its cancer-inhibiting properties reappeared. (more…)

Researchers Discover How Progesterone May Increase Breast Cancer Risk

By Guest PostJanuary 19, 2011Health, Scienceanastasia kariagina, breast cancer, cell growth, epidermal growth factor, estrogen, hormone, hormone dependent, hormone replacement therapy, human breast, mammary cancers, mammary cells, phenomenon, postmenopausal women, progesterone, progestin, protein amphiregulin, risk of breast cancer, sandra haslam, tumor growth

EAST LANSING, Mich. — Researchers have identified how the hormones progesterone and estrogen interact to increase cell growth in normal mammary cells and mammary cancers, a novel finding that may explain why postmenopausal women receiving hormone replacement therapy with estrogen plus progestin are at increased risk of breast cancer.

The discovery that both estrogen and progesterone must be present for the increased production of the protein amphiregulin, which binds to mammary cells and promotes cell growth, could lead to new treatment methods for the disease, said Sandra Haslam, director of Michigan State University’s Breast Cancer and the Environment Research Center and lead researcher on the project. (more…)

Tag Archives: tumor growth

Fat cells in breast may connect social stress to breast cancer

Common Antifungal Drug Decreases Tumor Growth and Shows Promise as Cancer Therapy

Yale Scientists Identify Gene That Controls The Spread of Melanoma

UF Researchers Find Quiet Protein Speaks Loudly in Fight Against Cancer

Researchers Discover How Progesterone May Increase Breast Cancer Risk