mammary glands – Shamskm: A site to exchange knowledge and solutions

Fat cells in breast may connect social stress to breast cancer

By Guest PostJune 23, 2013Healthacaca, acetyl coa carboxykase, acly, aggressive breast cancer, antigen mice, atp citrate lyase, breast, carcinoma in situ, chronic stress, erin wonder, estrogen, fat cells, female mice, gene, her2, hexokinase, hk2, hormones, leptin, lumpectomy, mammary fat, mammary glands, martha mcclintock, matthew brady, maxwell skor, metabolism, metabolism of glucose, multiple tissues, paul volden, progesterone, receptor, social stress, suzanne conzen, sv40 t, triple negative, tumor growth, tumors, university of chicago

Local chemical signals released by fat cells in the mammary gland appear to provide a crucial link between exposure to unrelenting social stressors early in life, and the subsequent development of breast cancer, researchers from the University of Chicago report in the July 2013 issue of the journal Cancer Prevention Research.

Some forms of stress exposure may be associated with an increased risk of certain types of aggressive breast cancer. But the mechanisms linking the biology of social stress to cancer have been hard to identify. To unravel that mechanism, the researchers looked for differences between mice raised in small groups and those that grow up in an isolated setting—an established model of chronic stress without social supports. (more…)

Exposed To Phthalates as Fetuses, Female Mice Have Altered Reproductive Lives

By Guest PostMarch 20, 2012Sciencebenjamin moyer, brown university, cell growth, chemical, concern list, corn oil, david orenstein, dehp, doses of phthalates, exposure scenario, female mouse fetuses, health effect, in utero, industrial chemical, mammary glands, mary hixon, mehp, mice, organism, Phthalates, plastics, precancerous lesions, reproductive lifespan, reproductive system, toxicology

Many environmental and public health officials are concerned about the potential health effects of phthalates, which are common chemicals used to make plastics softer and more pliable. In the first study to examine what effect in utero doses of phthalates have on the reproductive system of mice, Brown University toxicologists found that extremely high doses were associated with significant changes, such as a shortened reproductive lifespan and abnormal cell growth in mammary glands.

PROVIDENCE, R.I. [Brown University] — Female mouse fetuses exposed to very high doses of a common industrial chemical that makes plastics more pliable develop significant reproductive alterations and precancerous lesions as they grow up, according to a new toxicology study conducted at Brown University.

The administered doses of MEHP, the chemical that results when animals metabolize the industrial phthalate DEHP, were much higher than any normal environmental exposure that people or animals would encounter, said Mary Hixon, assistant professor of pathology and laboratory medicine (research) in The Warren Alpert Medical School of Brown University and a study co-author. (more…)

Tag Archives: mammary glands

Fat cells in breast may connect social stress to breast cancer

Exposed To Phthalates as Fetuses, Female Mice Have Altered Reproductive Lives