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UCLA Researchers Further Refine ‘Nanovelcro’ Device to Grab Single Cancer Cells from Blood

By Guest PostMarch 3, 2013Scienceact like velcro, analysis, angewandte chemie, antoni ribas, biopsy samples, blood, blood samples, braf v600e, cancer cells, cancer grow, circulate, circulating melanoma cells, circulating tumor cells, cmcs, configuration, ctcs, disease, dna structure, early stages, fatal metastases, fibers coated, genes, genetic analysis, genomic evolution, growth, hematology, histopathology, hsian rong tseng, jonsson cancer center, laser micro dissection, liquid biopsy, lmd, melanoma, melanoma cells, melanoma tumors, metastasis, method, microscopic structure, nanoscale technology, nanoscale wires, nanovelcro chip, new tumors, oncology, patient, polymer nanofiber, progression, protein antibodies, researchers, roger lo, single cell genotyping, skin cancer, tumors, ucla, velcro like, working mechanism

Improvement enables ‘liquid biopsies’ for metastatic melanoma

Researchers at UCLA report that they have refined a method they previously developed for capturing and analyzing cancer cells that break away from patients’ tumors and circulate in the blood. With the improvements to their device, which uses a Velcro-like nanoscale technology, they can now detect and isolate single cancer cells from patient blood samples for analysis.

Circulating tumor cells, or CTCs, play a crucial role in cancer metastasis, spreading from tumors to other parts of the body, where they form new tumors. When these cells are isolated from the blood early on, they can provide doctors with critical information about the type of cancer a patient has, the characteristics of the individual cancer and the potential progression of the disease. Doctors can also tell from these cells how to tailor a personalized treatment to a specific patient. (more…)

They Know The Drool

By Guest PostJanuary 30, 2012Health, Scienceactin, biomarkers, breast, cervical, clinical spit test, disease, epithelial cells, frank ondrey, heart disease, john carlis, life threatening cancer, lymphoma, melanoma, metastatic breast cancer, motions of cells, myosin, nelson rhodus, oral cancer, oral lesions, ovarian cancer, protein, proteomics, saliva, study of proteins, testing spit, timothy griffin, tissue cells, united states, university of minnesota

*The search for biomarkers of disease in spit*

It’s a researcher’s dream: a simple, noninvasive test to detect life-threatening cancer, heart disease, or other maladies while they’re still treatable.

A team of University of Minnesota researchers is in hot pursuit of that goal, using one of the simplest means imaginable: testing spit. They’ve discovered that conditions such as breast and oral cancer leak certain proteins into saliva, and if detected, such proteins can be “biomarkers” for the disease. (more…)

MU Researcher’s Photoacoustic Device Finds Cancer Cells Before They Become Tumors

By Guest PostJanuary 6, 2012Health, Scienceblack 18 wheeler, cancer cells, cancer studies, cellular level, ct, early diagnosis of metastatic melanoma, fda, john viator, laser induced ultrasound, melanoma, melanoma cancer detection, mri scans, photoacoustic detection method, photoacoustics, populations, skin cancer, tumors, university of missouri

*Commercial production will allow scientists, academia opportunity for use in cancer studies*

COLUMBIA, Mo. – Early detection of melanoma, the most aggressive skin cancer, is critical because melanoma will spread rapidly throughout the body. Now, University of Missouri researchers are one step closer to melanoma cancer detection at the cellular level, long before tumors have a chance to form. Commercial production of a device that measures melanoma using photoacoustics, or laser-induced ultrasound, will soon be available to scientists and academia for cancer studies. The commercial device also will be tested in clinical trials to provide the data required to obtain U.S. Food and Drug Administration approval for early diagnosis of metastatic melanoma and other cancers. (more…)

Yale Scientists Identify Gene That Controls The Spread of Melanoma

By Guest PostDecember 16, 2011Health, Sciencebeta catenin, braf gene, disease, drug treatments, gene, genetically altered mice, human melanoma, intestine, lungs, lymph nodes, malignant melanoma, manjula santhanakrishnan, marcus w bosenberg, melanoma, metastasis, skin, skin cancer, spleen, tumor growth, william damsky, yale cancer center

Yale Cancer Center researchers have identified a gene in melanoma that can dramatically affect the spread of the disease. The study, published in the journal Cancer Cell, provides new insight into how melanoma metastasizes in patients with advanced disease, and which organs are most likely to be affected. These findings could potentially lead to new drug treatments.

Malignant melanoma is the most deadly form of skin cancer, accounting for 80 percent of all skin cancer deaths. Nearly all melanoma deaths are a result of metastasis, which can occur early in the course of tumor growth in the skin. (more…)

Sun Safety: Facts about Skin Cancer and Tips on Preventing It

By Guest PostJune 3, 2011Healthbaseball cap, be sun smart, block ultraviolet (uv), broad-brim hat, crawl under a rock, dr. david leffell, good sun protection, head and neck, helen dodson, hide in the basement, kids ball games, melanoma, physicians of yale, prison uniform, radiation from skin, save your life, skin cancer prevention, squamous cell cancer, sun protective eyeglasses, sun-protective cloth, ultraviolet protective factor-rated, use of sunscreen, yale cancer center, yale medical group, yale university

With summer upon us, Yale Medical Group physicians have an urgent warning: Be sun smart. Practicing good sun protection, including the use of sunscreen, could save your life, they say.

“You don’t want to go crawl under a rock or hide in the basement,” says dermatologist Dr. David Leffell, CEO of Yale Medical Group and a member of Yale Cancer Center. “You want to be active and that usually is best done outdoors — simply use moderation and common sense.” (more…)

Researchers Discover Way to ‘Amp Up’ Power of Killer T Cells in Immune System

By Guest PostMay 22, 2011Health, Scienceanti tumor function, brain, cd8 cells, cd8 t cells, cytokines, dendritic cell vaccines, dominique lisiero, fight viruses, glioblastoma, il-12, imiquimod, immune system, interleukin-12, jonsson comprehensive cancer center, killer t cells, melanoma, models of metastatic melanoma, robert prins, tlrs, toll like receptors

Researchers at UCLA’s Jonsson Comprehensive Cancer Center have discovered a way to “amp up” the power of killer T cells known as CD8 cells in the immune system, making them more functional for longer periods of time and boosting their ability to multiply and expand within the body to fight melanoma.

The study, done in mouse models of metastatic melanoma that had spread to the brain, has important clinical implications, as the method could improve the cancer-killing power of experimental immunotherapies being tested now for various cancers, including deadly glioblastoma and metastatic melanoma, both of which are very difficult to treat successfully. (more…)

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