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UA Researchers Make Next Move in Fight Against Ovarian Cancer

By Guest PostMarch 31, 2019Healthfallopian tube removal, gynecologic cancer, hysteroscopy, jennifer barton, ovarian cancer, reconstructive surgery, salpingo oophorectomy, survival rate

A little scope with big impact could increase survival rates for cancer patients.

Ovarian cancer claims the highest mortality rate of all gynecologic cancers – as high as 70 percent – in part because the disease is rarely detected earlier than stage 3 or 4. When the disease is discovered early in its development, however, survival rates are high. An effective screening technique for early detection could not only save lives, but also drastically improve their quality. (more…)

UCLA scientists test new strategy that could help fight ovarian cancer

By Guest PostMarch 26, 2016Healthcancer therapy, cell death, guardian of genome, gynecologic tumors, kill cancer cells, ovarian cancer, ovarian cancer cells, protein fibers

Approach borrows from technique of inhibiting protein fibers that cause Alzheimer’s and Parkinson’s diseases

UCLA scientists have developed a promising novel method to treat gynecologic tumors. The approach focuses on a protein called p53, which is commonly mutated in women who have high-grade serous ovarian cancer, the deadliest form of reproductive cancer. In many women with the disease, the cancer is very advanced by the time it is diagnosed and is therefore difficult to treat. (more…)

Diagnostic Technique Uses Immune Cell DNA

By Guest PostJuly 10, 2012Scienceafrican american, bladder cancer, blood samples, brock christensen, brown university, carmen marsit, cd4, cell carcinoma, cell membrane, chemical alteration, devin koestler, DNA, granulocyte leukocytes, immune cell, karl kelsey, leukocytes, methylation, ovarian cancer, t lymphocytes

By looking at signature chemical differences in the DNA of various immune cells called leukocytes, scientists have developed a way to determine their relative abundance in blood samples. The relative abundance turns out to correlate with specific cancers and other diseases, making the technique, described in two recent papers, potentially valuable not only for research but also for diagnostics and treatment monitoring.

PROVIDENCE, R.I. [Brown University] — When a person is sick, there is a tell-tale sign in their blood: a different mix of the various types of immune cells called leukocytes. A group of scientists at several institutions including Brown University has discovered a way to determine that mix from the DNA in archival or fresh blood samples, potentially providing a practical new technology not only for medical research but also for clinical diagnosis and treatment monitoring of ailments including some cancers. (more…)

They Know The Drool

By Guest PostJanuary 30, 2012Health, Scienceactin, biomarkers, breast, cervical, clinical spit test, disease, epithelial cells, frank ondrey, heart disease, john carlis, life threatening cancer, lymphoma, melanoma, metastatic breast cancer, motions of cells, myosin, nelson rhodus, oral cancer, oral lesions, ovarian cancer, protein, proteomics, saliva, study of proteins, testing spit, timothy griffin, tissue cells, united states, university of minnesota

*The search for biomarkers of disease in spit*

It’s a researcher’s dream: a simple, noninvasive test to detect life-threatening cancer, heart disease, or other maladies while they’re still treatable.

A team of University of Minnesota researchers is in hot pursuit of that goal, using one of the simplest means imaginable: testing spit. They’ve discovered that conditions such as breast and oral cancer leak certain proteins into saliva, and if detected, such proteins can be “biomarkers” for the disease. (more…)

Ovarian Cancer Study Proves Drug Delays Disease Progression

By Guest PostJanuary 3, 2012Healthamerican study, amit oza, avastin, bevacizumab, blood vessels, brain, breast, canada, canadian cancer society, caz zyvatkauskas, colorectal, disease, drug, kidney, lung, oncologist, ovarian cancer, starving the cancer, timothy perren, tumours, university of toronto, women

*U of T, U.K. study focused on Avastin*

Treating ovarian cancer with the drug bevacizumab (“Avastin”) delays the disease and may also improve survival, according to an international clinical trial co-led by Drs. Amit Oza of the University of Toronto and Princess Margaret Hospital (PMH) and Timothy Perren of St James’s Institute of Oncology, Leeds, U.K.

The findings, published on Dec. 28 in the New England Journal of Medicine, report that the drug halted the cancer’s return for two months overall. However, for women with the highest risk disease, the delay was five to six months and in this group, the findings also indicate a strong trend to improved overall survival, which is being analysed until 2013. (more…)

Fat Cells in Abdomen Fuel Spread of Ovarian Cancer

By Guest PostNovember 4, 2011Health, Scienceabdominal cavity, breast cancer, cause of cancer deaths in women, energy dense lipids, ernst lengyel, fabp4, fat carrier, fat cells, fatty acid binding protein, fatty tissue, gastric and colon cancers, growth of ovarian cancer, healthy mice, hilary kenny, intestines, kristin nieman, nutrients, omentum, ovarian cancer, ovarian cancer cells, ovarian cancer metastasis, protein, protein signals, stomach, tumor cells, university of chicago

A large pad of fat cells that extends from the stomach and covers the intestines provides nutrients that promote the spread and growth of ovarian cancer, reports a University of Chicago-based research team in the journal Nature Medicine, published online Oct. 30.

Ovarian cancer, the fifth-leading cause of cancer deaths in women, tends to spread within the abdominal cavity as opposed to distant organs. In 80 percent of women, by the time ovarian cancer is diagnosed, it has spread to the pad of fat cells, called the omentum. Often, cancer growth in the omentum exceeds the growth of the original ovarian cancer. (more…)

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