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UCLA Researchers Further Refine ‘Nanovelcro’ Device to Grab Single Cancer Cells from Blood

By Guest PostMarch 3, 2013Scienceact like velcro, analysis, angewandte chemie, antoni ribas, biopsy samples, blood, blood samples, braf v600e, cancer cells, cancer grow, circulate, circulating melanoma cells, circulating tumor cells, cmcs, configuration, ctcs, disease, dna structure, early stages, fatal metastases, fibers coated, genes, genetic analysis, genomic evolution, growth, hematology, histopathology, hsian rong tseng, jonsson cancer center, laser micro dissection, liquid biopsy, lmd, melanoma, melanoma cells, melanoma tumors, metastasis, method, microscopic structure, nanoscale technology, nanoscale wires, nanovelcro chip, new tumors, oncology, patient, polymer nanofiber, progression, protein antibodies, researchers, roger lo, single cell genotyping, skin cancer, tumors, ucla, velcro like, working mechanism

Improvement enables ‘liquid biopsies’ for metastatic melanoma

Researchers at UCLA report that they have refined a method they previously developed for capturing and analyzing cancer cells that break away from patients’ tumors and circulate in the blood. With the improvements to their device, which uses a Velcro-like nanoscale technology, they can now detect and isolate single cancer cells from patient blood samples for analysis.

Circulating tumor cells, or CTCs, play a crucial role in cancer metastasis, spreading from tumors to other parts of the body, where they form new tumors. When these cells are isolated from the blood early on, they can provide doctors with critical information about the type of cancer a patient has, the characteristics of the individual cancer and the potential progression of the disease. Doctors can also tell from these cells how to tailor a personalized treatment to a specific patient. (more…)

Vitamin D, Omega-3 May Help Clear Amyloid Plaques Found in Alzheimer’s

By Guest PostFebruary 12, 2013Healthalzheimer, amyloid beta, amyloid beta absorption, amyloid plaques, avi siani, blood samples, brain, cell death, critical immune cells, dihydroxyvitamin d3, docosahexaenoic acid, eicosapentaenoic acid, fatty acid dha, fatty acid epa, fatty acids, guanghao liu, immune system, improve plaque clearance, inflammation, inflammatory genes, james sayre, larry magpantay, macrophages, mathew mizwicki, milan fiala, nutrition molecule, omega 3 dha, omega-3, oxidation, vitamin D, vitamin d3

A team of academic researchers has pinpointed how vitamin D3 and omega-3 fatty acids may enhance the immune system’s ability to clear the brain of amyloid plaques, one of the hallmarks of Alzheimer’s disease.

In a small pilot study published in the Feb. 5 issue of the Journal of Alzheimer’s Disease, the scientists identified key genes and signaling networks regulated by vitamin D3 and the omega-3 fatty acid DHA (docosahexaenoic acid) that may help control inflammation and improve plaque clearance. (more…)

Diagnostic Technique Uses Immune Cell DNA

By Guest PostJuly 10, 2012Scienceafrican american, bladder cancer, blood samples, brock christensen, brown university, carmen marsit, cd4, cell carcinoma, cell membrane, chemical alteration, devin koestler, DNA, granulocyte leukocytes, immune cell, karl kelsey, leukocytes, methylation, ovarian cancer, t lymphocytes

By looking at signature chemical differences in the DNA of various immune cells called leukocytes, scientists have developed a way to determine their relative abundance in blood samples. The relative abundance turns out to correlate with specific cancers and other diseases, making the technique, described in two recent papers, potentially valuable not only for research but also for diagnostics and treatment monitoring.

PROVIDENCE, R.I. [Brown University] — When a person is sick, there is a tell-tale sign in their blood: a different mix of the various types of immune cells called leukocytes. A group of scientists at several institutions including Brown University has discovered a way to determine that mix from the DNA in archival or fresh blood samples, potentially providing a practical new technology not only for medical research but also for clinical diagnosis and treatment monitoring of ailments including some cancers. (more…)

Vampire Bat Study May Lead to Better Rabies-Control Strategies

By Guest PostJune 14, 2012Nature, ScienceAmazon rainforest, badgers, bat colonies, blood samples, bovine, cattle, charles rupprecht, culling bats, daniel streicker, ebola, genetic studies, immune, infectious diseases, ivan vargas, joel montgomery, jorge gomez benavides, marburg hemorrhagic fevers, mathematical modelling, nipah encephalitis, pejman rohani, peru, rabies, rabies in peru, rabies infections, rabies virus, sars, sergio recuenco, south america, tuberculosis, united states, university of michigan, vacuum effect, vampire bats, vampiricide, víctor pacheco, wildlife disease, zoonotic diseases

ANN ARBOR, Mich.— A new study of rabies in vampire bats in Peru has found that culling bats—a common rabies control strategy—does not reduce rates of rabies exposure in bat colonies, and may even be counterproductive.

The findings may eventually help public health and agriculture officials in Peru develop more effective methods for preventing rabies infections in humans and livestock, according to a team of scientists from the United States and Peru led by Daniel Streicker, a postdoctoral associate at the University of Georgia Odum School of Ecology.

The study was published online this week in the Proceedings of the Royal Society B. The research team includes University of Michigan population ecologist Pejman Rohani. (more…)

Exercise and Healthy Eating Make a Difference Even Later in Life

By Guest PostJune 8, 2012Health, Sportsaging studies, american geriatrics society, blood samples, cardiovascular disease, carotenoids, emily nicklett, exercise, fruits, healthy diet, inflammation, jared wadley, johns hopkins university, life expectancy, mortality risk, physical activity, university of michigan, vegetables, women

ANN ARBOR, Mich.— Women in their 70s had a longer life expectancy when they exercised and regularly ate fruits and vegetables, a new University of Michigan study found.

“This is the first study to show that the combination of a healthy diet and greater physical activity predict greater survival and that the combination of both positive factors confers lower mortality risk than either factor alone,” said Emily Nicklett, U-M assistant professor of social work.

Nicklett and researchers at The Johns Hopkins University studied the results from 713 women ages 70 to 79 years who participated in the Women’s Health and Aging Studies. (more…)

Study of HIV Increase in Pakistan Could Benefit Other Research

By Guest PostAugust 26, 2011General, Healthafghanistan, aga khan university, behavioral data, blood samples, disease, dna sequences, dow university of health sciences, genetic evidence, hiv, hiv epidemic in pakistan, hiv positive groups, hiv strains, karachi, marco salemi, middle east, north africa, Pakistan, virus, willi mcfarland

GAINESVILLE, Fla. — Rates of HIV have increased in Pakistan’s general population, as the virus has spread beyond at-risk groups to women and their children, according to an international team of researchers, including a University of Florida scientist.

The researchers raise concern that the transmission across subgroups into Pakistan’s general population may serve as indication that the virus may be spreading into populations within neighboring Afghanistan. The team’s epidemiological findings were published in July in the journal PLoS One. (more…)

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