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UCLA Researchers Further Refine ‘Nanovelcro’ Device to Grab Single Cancer Cells from Blood

By Guest PostMarch 3, 2013Scienceact like velcro, analysis, angewandte chemie, antoni ribas, biopsy samples, blood, blood samples, braf v600e, cancer cells, cancer grow, circulate, circulating melanoma cells, circulating tumor cells, cmcs, configuration, ctcs, disease, dna structure, early stages, fatal metastases, fibers coated, genes, genetic analysis, genomic evolution, growth, hematology, histopathology, hsian rong tseng, jonsson cancer center, laser micro dissection, liquid biopsy, lmd, melanoma, melanoma cells, melanoma tumors, metastasis, method, microscopic structure, nanoscale technology, nanoscale wires, nanovelcro chip, new tumors, oncology, patient, polymer nanofiber, progression, protein antibodies, researchers, roger lo, single cell genotyping, skin cancer, tumors, ucla, velcro like, working mechanism

Improvement enables ‘liquid biopsies’ for metastatic melanoma

Researchers at UCLA report that they have refined a method they previously developed for capturing and analyzing cancer cells that break away from patients’ tumors and circulate in the blood. With the improvements to their device, which uses a Velcro-like nanoscale technology, they can now detect and isolate single cancer cells from patient blood samples for analysis.

Circulating tumor cells, or CTCs, play a crucial role in cancer metastasis, spreading from tumors to other parts of the body, where they form new tumors. When these cells are isolated from the blood early on, they can provide doctors with critical information about the type of cancer a patient has, the characteristics of the individual cancer and the potential progression of the disease. Doctors can also tell from these cells how to tailor a personalized treatment to a specific patient. (more…)

Breast Tenderness Following Combo Hormone Therapy Linked To Increased Breast Density

By Guest PostOctober 23, 2011Health, Sciencebaseline breast density in mammograms, breast cell proliferation, breast tenderness, breast tissue growth, breasts, carolyn crandall, changes in breast density, combination estrogen and progestin therapy, combination therapy, dense breasts, development of breast tenderness, estrogen therapy, hormone therapy, hysterectomy, jonsson cancer center, mammographic density, placebo, post menopausal women, risk of breast cancer, risk of uterine cancer, whi

*Study examines biology underlying link between tenderness, cancer risk*

Post-menopausal women who experience breast tenderness after starting combination hormone therapy have a higher risk of breast cancer than women who don’t, a study by researchers with UCLA’s Jonsson Comprehensive Cancer Center has shown. One reason for this, they now say, may be that these women’s breasts are becoming more dense.

Such new-onset tenderness was found to be more pronounced after the start of combination estrogen-and-progestin therapy than with estrogen therapy alone. The link between new-onset tenderness and changes in breast density also was more pronounced in women on combination therapy, said the study’s first author, Dr. Carolyn Crandall, a UCLA professor of general internal medicine and a scientist with the Jonsson Cancer Center. (more…)

New Method helps Researchers Zero in on Drugs that can kill Brain Cancer Stem Cells

By Guest PostOctober 17, 2011Health, Sciencebiobehavioral sciences, brain cancer, brain tumors, dr. harley kornblum, glioblastoma, identify chemical compounds, jonsson cancer center, kill the stem cells, malignancies, molecular cancer therapeutics, new cancer drugs, new screening approach, seven chemical libraries, treatment-resistant, tumor cells, typical screening, ucla's jonsson comprehensive cancer center, university of california

Researchers with UCLA’s Jonsson Comprehensive Cancer Center have developed a new screening approach to identify chemical compounds that can target and kill the stem cells responsible for creating deadly brain tumors.

Glioblastoma is one of the deadliest malignancies, typically killing patients within 12 to 18 months. These brain cancers consist of two kinds of cells: a larger, heterogeneous population of tumor cells and a smaller sub-population of stem cells, which are treatment-resistant. (more…)

Tag Archives: jonsson cancer center

UCLA Researchers Further Refine ‘Nanovelcro’ Device to Grab Single Cancer Cells from Blood

Breast Tenderness Following Combo Hormone Therapy Linked To Increased Breast Density

New Method helps Researchers Zero in on Drugs that can kill Brain Cancer Stem Cells