post menopausal women – Shamskm: A site to exchange knowledge and solutions

Gene Research Sheds Light on Timing of Menopause

By Guest PostJanuary 23, 2012Healthanna murray, breast cancer, cardiovascular disease, damage, early menopause, genes, genetic studies, genome, heart disease, hormonal change, hormonal regulation, immune system, joanne murabito, john perry, kathryn lunetta, menopause, menopause onset, oestrogen exposure, post menopausal women, pre menopausal, repair, reproductive disorders, reproductive lifespan, timing of menopause, university of exeter, university of oxford

An international team of researchers has discovered 13 new regions of the genome associated with the timing of menopause.

These genes shed light on the biological pathways involved in reproductive lifespan and will provide insights into conditions connected to menopause, such as breast cancer and heart disease.

Menopause is a major hormonal change that affects most women when they are in their early 50s. The timing of menopause can have a huge impact on fertility, as well as influencing the risk of a range of common diseases such as breast cancer. It has been known for some time that genetic factors influenced the onset of menopause, however until recently very few genes had been identified.

In the new study, published in the journal Nature Genetics on 22 January 2012, Dr Anna Murray, University of Exeter, Peninsula College of Medicine and Dentistry (PCMD) Dr John Perry, PCMD and WTCHG, University of Oxford, and dozens of international collaborators, examined the genomes of over 50,000 women. They identified 13 novel gene regions associated with menopause onset, and confirmed four previously identified. Most of the 17 regions include genes related to DNA damage/repair or the immune system, whilst others are linked to hormonal regulation. (more…)

Breast Tenderness Following Combo Hormone Therapy Linked To Increased Breast Density

By Guest PostOctober 23, 2011Health, Sciencebaseline breast density in mammograms, breast cell proliferation, breast tenderness, breast tissue growth, breasts, carolyn crandall, changes in breast density, combination estrogen and progestin therapy, combination therapy, dense breasts, development of breast tenderness, estrogen therapy, hormone therapy, hysterectomy, jonsson cancer center, mammographic density, placebo, post menopausal women, risk of breast cancer, risk of uterine cancer, whi

*Study examines biology underlying link between tenderness, cancer risk*

Post-menopausal women who experience breast tenderness after starting combination hormone therapy have a higher risk of breast cancer than women who don’t, a study by researchers with UCLA’s Jonsson Comprehensive Cancer Center has shown. One reason for this, they now say, may be that these women’s breasts are becoming more dense.

Such new-onset tenderness was found to be more pronounced after the start of combination estrogen-and-progestin therapy than with estrogen therapy alone. The link between new-onset tenderness and changes in breast density also was more pronounced in women on combination therapy, said the study’s first author, Dr. Carolyn Crandall, a UCLA professor of general internal medicine and a scientist with the Jonsson Cancer Center. (more…)

Tag Archives: post menopausal women

Gene Research Sheds Light on Timing of Menopause

Breast Tenderness Following Combo Hormone Therapy Linked To Increased Breast Density