Tag Archives: pre menopausal

Gene Research Sheds Light on Timing of Menopause

An international team of researchers has discovered 13 new regions of the genome associated with the timing of menopause.

These genes shed light on the biological pathways involved in reproductive lifespan and will provide insights into conditions connected to menopause, such as breast cancer and heart disease.

Menopause  is a major hormonal change that affects most women when they are in their early 50s. The timing of menopause can have a huge impact on fertility, as well as influencing the risk of a range of common diseases such as breast cancer. It has been known for some time that genetic factors influenced the onset of menopause, however until recently very few genes had been identified.

In the new study, published in the journal Nature Genetics on 22 January 2012, Dr Anna Murray, University of Exeter, Peninsula College of Medicine and Dentistry (PCMD) Dr John Perry, PCMD and WTCHG, University of Oxford, and dozens of international collaborators, examined the genomes of over 50,000 women. They identified 13 novel gene regions associated with menopause onset, and confirmed four previously identified. Most of the 17 regions include genes related to DNA damage/repair or the immune system, whilst others are linked to hormonal regulation. (more…)

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