New findings show that eating a high-fat diet beginning at puberty speeds up the development of breast cancer and may actually increase the risk of cancer similar to a type often found in younger adult women.
The research comes from the Breast Cancer and the Environment Research Program at Michigan State University and is published in the current online issue of Breast Cancer Research. (more…)
Researchers at Michigan State University have discovered a protein that does its best work with one foot in the grave.
The study, which appears in the current issue of the Journal of Biological Chemistry, focuses on the nontraditional lifestyle of Retinoblastoma tumor suppressor proteins, which could lead to new ways to treat cancer.
“Retinoblastoma proteins are unique in that they use controlled destruction to do their jobs in a timely but restrained fashion,” said Liang Zhang, a lead author and MSU cell and molecular biology graduate student. “This is an unusual way for proteins to act.” (more…)
COLUMBUS, Ohio – Women who are obese before they become pregnant are at higher risk of having children with lower cognitive function – as measured by math and reading tests taken between ages 5 to 7 years – than are mothers with a healthy prepregnancy weight, new research suggests.
In this large observational study, prepregnancy obesity was associated, on average, with a three-point drop in reading scores and a two-point reduction in math scores on a commonly used test of children’s cognitive function. (more…)
Many environmental and public health officials are concerned about the potential health effects of phthalates, which are common chemicals used to make plastics softer and more pliable. In the first study to examine what effect in utero doses of phthalates have on the reproductive system of mice, Brown University toxicologists found that extremely high doses were associated with significant changes, such as a shortened reproductive lifespan and abnormal cell growth in mammary glands.
PROVIDENCE, R.I. [Brown University] — Female mouse fetuses exposed to very high doses of a common industrial chemical that makes plastics more pliable develop significant reproductive alterations and precancerous lesions as they grow up, according to a new toxicology study conducted at Brown University.
The administered doses of MEHP, the chemical that results when animals metabolize the industrial phthalate DEHP, were much higher than any normal environmental exposure that people or animals would encounter, said Mary Hixon, assistant professor of pathology and laboratory medicine (research) in The Warren Alpert Medical School of Brown University and a study co-author. (more…)
AUSTIN, Texas — University of Texas at Austin researchers have demonstrated a new and more effective method for regrowing blood vessels in the heart and limbs — a research advancement that could have major implications for how we treat heart disease, the leading cause of death in the Western world.
The treatment method developed by Cockrell School of Engineering Assistant Professor Aaron Baker could allow doctors to bypass surgery and instead repair damaged blood vessels simply by injecting a lipid-incased substance into a patient. Once inside the body, the substance stimulates cell growth and spurs the growth of new blood vessels from pre-existing ones. (more…)
EAST LANSING, Mich. — Researchers have identified how the hormones progesterone and estrogen interact to increase cell growth in normal mammary cells and mammary cancers, a novel finding that may explain why postmenopausal women receiving hormone replacement therapy with estrogen plus progestin are at increased risk of breast cancer.
The discovery that both estrogen and progesterone must be present for the increased production of the protein amphiregulin, which binds to mammary cells and promotes cell growth, could lead to new treatment methods for the disease, said Sandra Haslam, director of Michigan State University’s Breast Cancer and the Environment Research Center and lead researcher on the project. (more…)
