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Right Target, but Missing the Bulls-Eye for Alzheimer’s

By Guest PostFebruary 3, 2013Health, Scienceabeta, abeta40, abeta42, abeta42 protein, aleksey lomakin, alzheimer's disease, america, amino acids, amyloid beta, atul deshpande, brain, bulls eye, causes of death, chemical synthesis, computer simulations, david teplow, destroy neurons, disorder, george b benedek, gregory cole, hairpin like structure, late life dementia, mingfeng yang, molecular biology, mutant abeta peptides, pearl necklace, plaques, protein, robin roychaudhuri, sally frautschy, sequence, toxic actions, toxic form, ucla

UCLA researchers discover new point of attack for drug therapy

Alzheimer’s disease is the most common cause of late-life dementia. The disorder is thought to be caused by a protein known as amyloid-beta, or Abeta, which clumps together in the brain, forming plaques that are thought to destroy neurons. This destruction starts early, too, and can presage clinical signs of the disease by up to 20 years.

For decades now, researchers have been trying, with limited success, to develop drugs that prevent this clumping. Such drugs require a “target” — a structure they can bind to, thereby preventing the toxic actions of Abeta. (more…)

Scientists Pinpoint How Vitamin D May Help Clear Amyloid Plaques Found in Alzheimer’s

By Guest PostMarch 10, 2012Health1a 25 dihydroxyvitamin d3, alzheimer, amyloid beta, amyloid beta protein, antonio barrientos duran, blood, brain, calcium, chemical, chloride channel 3, clc3, component, curcumin, curcuminoids, danusa menegaz, disease, enzymatic conversion, gene, immune cells, immune system, intracellular mechanism, kidneys, liver, macrophages, mathew t mizwicki, milan fiala, patrick r griffin, phagocytosis, plaques, therapy, turmeric spice, vitamin d3

A team of academic researchers has identified the intracellular mechanisms regulated by vitamin D3 that may help the body clear the brain of amyloid beta, the main component of plaques associated with Alzheimer’s disease.

Published in the March 6 issue of the Journal of Alzheimer’s Disease, the early findings show that vitamin D3 may activate key genes and cellular signaling networks to help stimulate the immune system to clear the amyloid-beta protein. (more…)

New Ability To Regrow Blood Vessels Holds Promise For Treatment of Heart Disease

By Guest PostFebruary 11, 2012Scienceaaron baker, austin, blood vessels, cell growth, cell receptor, cellular differentiation, central ischemia, chronic myocardial ischemia, clinical disease, coreceptor, coronary vessel, disease, extra component, fgf 2, fibroblast growth factor 2, growth factor, heart, hindlimb ischemia, limbs, lipid based nanoparticles, lipid embedded receptor, lipid incased substance, organ dysfunction, patient, plaques, rats, revascularization approach, smoking, syndecan 4, synthetic, university of texas, western world

AUSTIN, Texas — University of Texas at Austin researchers have demonstrated a new and more effective method for regrowing blood vessels in the heart and limbs — a research advancement that could have major implications for how we treat heart disease, the leading cause of death in the Western world.

The treatment method developed by Cockrell School of Engineering Assistant Professor Aaron Baker could allow doctors to bypass surgery and instead repair damaged blood vessels simply by injecting a lipid-incased substance into a patient. Once inside the body, the substance stimulates cell growth and spurs the growth of new blood vessels from pre-existing ones. (more…)

Tag Archives: plaques

Right Target, but Missing the Bulls-Eye for Alzheimer’s

Scientists Pinpoint How Vitamin D May Help Clear Amyloid Plaques Found in Alzheimer’s

New Ability To Regrow Blood Vessels Holds Promise For Treatment of Heart Disease