Tag Archives: sequence

Discovery spotlights key role of mystery RNA modification in cells

By Guest PostJanuary 16, 2014Sciencecell differentiation, cells, chuan he, demethylation, deoxyribonucleic acid, diabetes, discovery, DNA, exact function, healthy cells, infertility, key role, m6a, messenger ribonucleic acid, methyl, methylation, mrna, mrna in question, mystery, n6 methyladenosine, neurobiology, obesity, organic compounds, parameter, peking university, proteins, regulating mrna lifetime, rna modification, san diego, sequence, university of california, university of chicago, xiao wang, ythdf2

Researchers had known for several decades that a certain chemical modification exists on messenger ribonucleic acid (mRNA), which is essential to the flow of genetic information. But only recently did experiments at the University of Chicago show that one major function of this modification governs the longevity and decay of RNA, a process critical to the development of healthy cells.

The chemical modification on mRNA in question is called N⁶-methyladenosine (m⁶A). A recent study by UChicago scientists reveals how the m⁶A modification on mRNA could affect the half-life of mRNA that in turn regulates cellular protein quantities. That discovery could provide fundamental insights into healthy functioning and disorders such as obesity, diabetes and infertility. (more…)

Scientists sequence genome of ‘sacred lotus,’ which likely holds anti-aging secrets

By Guest PostJune 7, 2013Health, Scienceanti aging secrets, australia, China, chinese academy, corn, crops, crysten blaby haas, disease, evolution, genetic defects, genetic endowment, genetic repair mechanisms, genome, germination defects, human health, humans, jane shen miller, Japan, liaoning province, longevity, molecular biologists, nelumbo nucifera, northeastern china, origin of life, powerful genetic system, rice, robert vanburen, sabeeha merchant, sacred lotus, sciences, scientists, sequence, shaohua li, spiritual purity, symbol, university of Illinois, unusual genetics, urbana-champaign, US, wheat, william schopf, wuhan botanical garden

A team of 70 scientists from the U.S., China, Australia and Japan today reports having sequenced and annotated the genome of the “sacred lotus,” which is believed to have a powerful genetic system that repairs genetic defects, and may hold secrets about aging successfully. The scientists sequenced more than 86 percent of the nearly 27,000 genes of the plant, Nelumbo nucifera, which is revered in China and elsewhere as a symbol of spiritual purity and longevity.

“The lotus genome is an ancient one, and we now know its ABCs,” said Jane Shen-Miller, one of three corresponding authors of the research and a senior scientist with UCLA’s Center for the Study of Evolution and the Origin of Life. “Molecular biologists can now more easily study how its genes are turned on and off during times of stress and why this plant’s seeds can live for 1,300 years. This is a step toward learning what anti-aging secrets the sacred lotus plant may offer.” (more…)

Endangered Lemurs’ Genomes Sequenced

By Guest PostMarch 31, 2013Natureaakrosh ratan, african agriculturalists, anthropologist, aquarium, aye aye populations, aye ayes, biologist, dna samples, ecological niche, edward louis, endangered lemur, european descent, forest habitats, fragmentation, Galaxy, genetically distinct, genome, george perry, henry doorly zoo, human dna sequence, human genetic diversity, loss, Madagascar, madagascar biodiversity, national science foundation, omaha, open source, oscar bedoya reina, penn state university, population, regions of madagascar, richard burhans, sequence, simon malcomber, software, southeast asian, stephan schuster, type of lemur, webb miller, woodpecker

Three populations of aye-ayes on Madagascar studied

For the first time, the complete genomes of three populations of aye-ayes–a type of lemur–have been sequenced and analyzed.

The results of the genome-sequence analyses are published this week in the journal Proceedings of the National Academy of Sciences (PNAS). (more…)

Fungi, Fungi Everywhere

By Guest PostFebruary 16, 2013Environmentantibiotics, archaea, bacteria, carbon, coasts of oregon, contamination, deep sea fungi, e coli bacteria, elements, Environment, fungi, fungi population, genetic material, inactive spores, industrial applicable enzymes, jennifer biddle, microbes bacteria, namibia, ocean environments, oceanographic institution, organism, peru, ribosomal ribonucleic acid, rrna, seafloor, sequence, single celled, strong indication, sunlight, university of delaware, virginia edgcomb, william orsi, woods hole

New research shows fungi living beneath the seafloor are widespread

Fungi living beneath the seafloor are widespread in ocean environments around the world, according to a new paper by scientists at the University of Delaware and Woods Hole Oceanographic Institution.

“They’re ubiquitous,” said co-author Jennifer Biddle, assistant professor of marine biosciences at UD’s College of Earth, Ocean, and Environment. “They are everywhere.” (more…)

Right Target, but Missing the Bulls-Eye for Alzheimer’s

By Guest PostFebruary 3, 2013Health, Scienceabeta, abeta40, abeta42, abeta42 protein, aleksey lomakin, alzheimer's disease, america, amino acids, amyloid beta, atul deshpande, brain, bulls eye, causes of death, chemical synthesis, computer simulations, david teplow, destroy neurons, disorder, george b benedek, gregory cole, hairpin like structure, late life dementia, mingfeng yang, molecular biology, mutant abeta peptides, pearl necklace, plaques, protein, robin roychaudhuri, sally frautschy, sequence, toxic actions, toxic form, ucla

UCLA researchers discover new point of attack for drug therapy

Alzheimer’s disease is the most common cause of late-life dementia. The disorder is thought to be caused by a protein known as amyloid-beta, or Abeta, which clumps together in the brain, forming plaques that are thought to destroy neurons. This destruction starts early, too, and can presage clinical signs of the disease by up to 20 years.

For decades now, researchers have been trying, with limited success, to develop drugs that prevent this clumping. Such drugs require a “target” — a structure they can bind to, thereby preventing the toxic actions of Abeta. (more…)

Training Improves Recognition of Rapid-Fire Objects

By Guest PostJuly 12, 2012Scienceattentional blink, attentional function, brain activity, brown university, fmri machine, gibberish character, hoon choi, Kazuhisa Shibata, li hung chang, perception, rapid fire objects, sequence, Takeo Watanabe, visual perception

“Attentional blink” is the term psychologists use to describe our inability to recognize a second important object if we see it less than half a second after a first one. It always seemed impossible to overcome, but in a new paper in the Proceedings of the National Academy of Sciences, Brown University psychologists report they’ve found a way.

PROVIDENCE, R.I. [Brown University] — So far it has seemed an irreparable limitation of human perception that we strain to perceive things in the very rapid succession of, say, less than half a second. Psychologists call this deficit “attentional blink.” We’ll notice that first car spinning out in our path, but maybe not register the one immediately beyond it. It turns out, we can learn to do better after all. In a new study researchers now based at Brown University overcame the blink with just a little bit of training that was never been tried before. (more…)

It’s in the Genes: Research Pinpoints How Plants Know When to Flower

By Guest PostMay 27, 2012Nature, Scienceandrew millar, arabidopsis, barley, benjamin to, biofuels, biology, circadian clock, factors, fkf1 protein, flowering locus t, flowering plants, know, mathematical model, molecular changes, molecular events, photoreceptor, plant, plants, prediction, protein, robert smith, sandra hines, scientists, sequence, shoot apex, sunlight, takato imaizumi, time keeping mechanism, university of edinburgh, university of washington, uw lab, wheat, when to flower, young hun song

Scientists believe they’ve pinpointed the last crucial piece of the 80-year-old puzzle of how plants “know” when to flower.

Determining the proper time to flower, important if a plant is to reproduce successfully, involves a sequence of molecular events, a plant’s circadian clock and sunlight.

Understanding how flowering works in the simple plant used in this study – Arabidopsis – should lead to a better understanding of how the same genes work in more complex plants grown as crops such as rice, wheat and barley, according to Takato Imaizumi, a University of Washington assistant professor of biology and corresponding author of a paper in the May 25 issue of the journal Science. (more…)

Sailing in a Sea of Microbes

By Guest PostMarch 4, 2012Sciencealgae, Arctic, atmospheric chemistry, bacteria, biogeochemical cycles, biomass, carbon dioxide, Chile, climate, daniel stolte, easter island, Environment, food production, genome, Germany, global warming, grassroots initiative, greenhouse gas, matt sullivan, melissa duhaime, microbe, ocean water, oceans, oxygen production, pacific ocean, research vessel, saguaro cacti, sequence, tara oceans, ua, university of arizona, wolves, world of viruses, world of webs

Researchers led by Matt Sullivan at the UA are among the first to dive into the world of viruses drifting through the world’s oceans.

Surrounded by the deep blue of the Pacific Ocean stretching from horizon to horizon, a lonely dot is glinting in the sun. It is the aluminum hull of a sailboat, a 118-foot schooner with white sails billowing from two masts.

On the deck, crewmembers and scientists are milling about. Commands are flying back and forth, and soon a strange contraption consisting of tubes clustered around an array of sensors dangling from a crane is lowered into the water, until it disappears in the clear blue depths. (more…)