Berkeley Lab scientist Ee-Been Goh thrives on re-engineering bacteria and mentoring students.
To see biochemist Ee-Been Goh in the lab today, figuring out how to rewire bacteria to produce biofuels, one would never guess she was once so uninterested in school that she barely made it through junior high. (more…)
Enzymes evolved in the lab hold commercial and scientific promise
Whether big, small, slimy, or tall, most animal bodies are symmetric.
Except for sea anemones, starfish, sponges, and the like, animals have bilateral, or right-left, symmetry. Us included.
The bilateral body plan became the norm over eons of evolution. But what about molecules? Have any evolved common structures like a body plan? (more…)
TeselaGen’s DNA construction technology makes genetic engineering cheaper and faster.
Sequencing, splicing and expressing DNA may seem to be the quintessence of cutting-edge science—indeed DNA manipulation has revolutionized fields such as biofuels, chemicals and medicine. But in fact, the actual process can still be tedious and labor-intensive, something Lawrence Berkeley National Laboratory (Berkeley Lab) scientist Nathan Hillson learned the hard way.
After struggling for two days to design a protocol to put together a genetic circuit with 10 pieces of DNA—using a spreadsheet as his primary tool—he was dismayed to discover that an outside company could have done the whole thing, including parts and labor, for lower cost than him ordering the oligonucleotides himself. “I learned two things: one, I never wanted to go through that process again, and two, it’s extremely important to do the cost-effectiveness calculation,” said Hillson, a biochemist who also directs the synthetic biology program at the Berkeley Lab-led Joint BioEnergy Institute (JBEI). “So that was the genesis of the j5 software. This is the perfect thing to teach a computer to do.” (more…)
*ARPA-E funded project aims to produce fuel molecules in plant leaves*
Mention biofuels and most people think of corn ethanol. Some may think of advanced biofuels from switchgrass or miscanthus. But tobacco? Not likely.
That could change. A team of scientists led by a researcher from the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) is exploring a way to produce gasoline, diesel, and jet fuel from the iconic plant of the South. (more…)
*Joint BioEnergy Institute Researchers Develop CAD-Type Tools for Engineering RNA Control Systems*
The computer assisted design (CAD) tools that made it possible to fabricate integrated circuits with millions of transistors may soon be coming to the biological sciences. Researchers at the U.S. Department of Energy (DOE)’s Joint BioEnergy Institute (JBEI) have developed CAD-type models and simulations for RNA molecules that make it possible to engineer biological components or “RNA devices” for controlling genetic expression in microbes. This holds enormous potential for microbial-based sustainable production of advanced biofuels, biodegradable plastics, therapeutic drugs and a host of other goods now derived from petrochemicals. (more…)
EAST LANSING, Mich. — Pretreating non-edible biomass – corn leaves, stalks or switch grass – holds the keys for unlocking its energy potential and making it economically viable, according to a team of researchers led by Michigan State University. (more…)
California is showing the way for the rest of the nation in terms of reducing greenhouse gas emissions, having set an ambitious goal to reduce these emissions to 80 percent below 1990 levels by the year 2050. Given that energy demand is projected to double by 2050, experts agree that the state will have to dramatically overhaul its energy systems to achieve its greenhouse gas emission goals.
At the 2011 Annual Meeting of the American Association for the Advancement of Science, some of the specific challenges and issue ahead were discussed in a session titled “Portraits of the California Energy System in 2050: Cutting Emissions by 80 Percent.” Contributing to this discussion were two scientists from Berkeley Lab and one from the Energy Biosciences Institute (EBI), in which Berkeley Lab is a partner. (more…)
Blake Simmons (left) and Harvey Blanch of the Joint BioEnergy Institute led the development of a technoeconomic model for optimizing biorefinery operations. Image cedit: Roy Kaltschmidt, Berkeley Lab Public Affairs
Researchers at the U.S. Department of Energy’s Joint BioEnergy Institute (JBEI) have created a technoeconomic model that should help accelerate the development of a next generation of clean, green biofuels that can compete with gasoline in economics and well as performance. This on-line, wiki-based model enables researchers to pursue the most promising strategies for cost-efficient biorefinery operations by simulating such critical factors as production costs and energy balances under different processing scenarios.
“The high production cost of biofuels has been the main factor limiting their widespread adoption,” says JBEI’s Daniel Klein-Marcuschamer. “We felt that a model of the biorefinery operation that was open, transparent about the assumptions it uses, and updatable by the community of users could aid in guiding research in the direction where it is most likely to reduce the production cost of biofuels.” (more…)
