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Lack of Protein Sp2 Disrupts Neuron Creation in Brain

By Guest PostJanuary 21, 2013Sciencecancer research, cell cycle regulator, cerebral cortex, creation of neurons, experimental mice, function of sp2, genetic tools, guanxi xiao, haifeng yin, how protein works, huixuan liang, jon horowitz, mechanism, neural therapies, neurodevelopmental diseases, north Carolina, offspring, program stem cell, protein, regeneration, regenerative medicine, simon hippenmeyer, skin, sp2, state university, stem cells, troy ghashghaei, tumor

A protein known as Sp2 is key to the proper creation of neurons from stem cells, according to researchers at North Carolina State University. Understanding how this protein works could enable scientists to “program” stem cells for regeneration, which has implications for neural therapies.

Troy Ghashghaei and Jon Horowitz, both faculty in NC State’s Department of Molecular Biomedical Sciences and researchers in the Center for Comparative Medicine and Translational Research, wanted to know more about the function of Sp2, a cell cycle regulator that helps control how cells divide. Previous research from Horowitz had shown that too much Sp2 in skin-producing stem cells resulted in tumors in experimental mice. Excessive amounts of Sp2 prevented the stem cells from creating normal cell “offspring,” or skin cells. Instead, the stem cells just kept producing more stem cells, which led to tumor formation. (more…)

Common Food Preservative May Slow, Even Stop Tumor Growth

By Guest PostOctober 30, 2012Healthanti tumor, antibacterial agent, antimicrobial, bacteria, bad cell, calcium, cancer fighting, cancer medicine, cancerous tumor, cell carcinoma, cell death, cell head, cell membrane, chac1, fda, food preservative, good cell, human consumption, key regulator, michigan, neck cancer, nisin, nisin treatment, oral cancer, potential, properties, protein, squamous, therapy, tumor, university, yvonne kapila

ANN ARBOR — Nisin, a common food preservative, may slow or stop squamous cell head and neck cancers, a University of Michigan study found.

What makes this particularly good news is that the Food and Drug Administration and the World Health Organization approved nisin as safe for human consumption decades ago, says Yvonne Kapila, the study’s principal investigator and professor at the University of Michigan School of Dentistry. (more…)

Breakthrough Technique Images Breast Tumors in 3-D with Great Clarity, Reduced Radiation

By Guest PostOctober 23, 2012Health, Science3d picture, alberto mittone, aniko sztrokay, blind evaluation, bone, breakthrough, breast cancer, breast tissue, computing algorithm, ct scanner, digital, dual view, equally sloped tomography, est, european, european colleague, france, Germany, image, jianwei miao, ludwig maximilians university, mammogram, mammography, maximilian reiser, oscillation, paola coan, patient, paul claude diemoz, radiation, radiation facility, researcher, scientist, screening, sergei gasilov, susanne liebhardt, synchrotron, technique, three-dimensional, tomography, tumor, ucla, united states, xray, yunzhe zhao, zhifeng huang

Like cleaning the lenses of a foggy pair of glasses, scientists are now able to use a technique developed by UCLA researchers and their European colleagues to produce three-dimensional images of breast tissue that are two to three times sharper than those made using current CT scanners at hospitals. The technique also uses a lower dose of X-ray radiation than a mammogram.

These higher-quality images could allow breast tumors to be detected earlier and with much greater accuracy. One in eight women in the United States will be diagnosed with breast cancer during her lifetime.

The research is published the week of Oct. 22 in the early edition of the journal Proceedings of the National Academy of Sciences. (more…)

Gold Nanoparticle Prostate Cancer Treatment Found Safe in Dogs, MU Study Shows

By Guest PostOctober 16, 2012Healthancer death, bodily function, cancer, cancer patient, cause, chemotherapy, clinical trial, dose, efficient way, gold nanoparticle, human patient, kattesh katti, missouri, mizzou advantage, one health, one medicine area, prostate cancer, prostate tumor, radioactive, reduction, sandra axiak bechtel, side effect, toxic, travel, treatment, tumor, tumor volume, university, us men, vital organ

New treatment may have fewer side effects than traditional cancer therapy

COLUMBIA, Mo. — Currently, large doses of chemotherapy are required when treating certain forms of cancer, resulting in toxic side effects. The chemicals enter the body and work to destroy or shrink the tumor, but also harm vital organs and drastically affect bodily functions. Now, scientists at the University of Missouri have proven that a new form of prostate cancer treatment that uses radioactive gold nanoparticles, and was developed at MU, is safe to use in dogs. Sandra Axiak-Bechtel, an assistant professor in oncology at the MU College of Veterinary Medicine, says that this is a big step for gold nanoparticle research.

“Proving that gold nanoparticles are safe to use in the treatment of prostate cancer in dogs is a big step toward gaining approval for clinical trials in men,” Axiak-Bechtel said. “Dogs develop prostate cancer naturally in a very similar way as humans, so the gold nanoparticle treatment has a great chance to translate well to human patients.” (more…)

Gold Nanoparticles Could Treat Prostate Cancer With Fewer Side Effects than Chemotherapy, MU Researchers Find

By Guest PostJuly 20, 2012Healthanandhi upendran, cathy cutler, charles caldwell, chemotherapy, gold nanoparticle, half life, kattesh katti, nanoparticle, prostate, prostate cancer, prostate tumor, radioactive, radioactive seeds, raghuraman kannan, tea, treatment, tumor, tumor cell, university of missouri

In new study published in PNAS, scientists found that nanoparticles, produced from chemicals in tea, reduced tumors by 80 percent.

COLUMBIA, Mo. – Currently, large doses of chemotherapy are required when treating certain forms of cancer, resulting in toxic side effects. The chemicals enter the body and work to destroy or shrink the tumor, but also harm vital organs and drastically affect bodily functions. Now, University of Missouri scientists have found a more efficient way of targeting prostate tumors by using gold nanoparticles and a compound found in tea leaves. This new treatment would require doses that are thousands of times smaller than chemotherapy and do not travel through the body inflicting damage to healthy areas. The study is being published in the Proceedings of the National Academy of Science. (more…)

Scientists Use PET to Predict Increased Survival in Cancer Patients After First Chemo Cycle

By Guest PostApril 10, 2012Sciencechemotherapy drugs, ct scan, cycle, fdg, fritz eilber, metabolic activity, molecular imaging tools, neoadjuvant chemotherapy, patient, pet scan, soft tissue sarcomas, survival rate, tumor

Researchers from UCLA’s Jonsson Comprehensive Cancer Center have found that by administering a PET scan to individuals with soft-tissue sarcomas after just a single cycle of neoadjuvant chemotherapy, they can predict increased survival in these patients.

Prior research by this multidisciplinary team of physician-scientists had shown that a combined PET/CT scan using a glucose uptake probe called FDG allowed them to determine the pathologic response of patients’ tumors after the first dose of chemotherapy drugs. They then wondered if the patients who showed a significant PET response after the first round of chemotherapy also were surviving longer. (more…)

‘Bed-of-Nails’ Breast Implant Deters Cancer Cells

By Guest PostMarch 26, 2012Healthbed of nails, blood vessel, breast cancer, brown university, cancer tumor, cell, cell function, chemical analysis, electron spectroscopy, lijuan zhang, malignant, michael platek, nanoscale, Nanotechnology, plga, protein, regrowth, thomas webster, tumor, united states, university of rhode island, vegf

Researchers at Brown University have created an implant that appears to deter breast cancer cell regrowth. Made from a common federally approved polymer, the implant is the first to be modified at the nanoscale in a way that causes a reduction in the blood-vessel architecture that breast cancer tumors depend upon, while also attracting healthy breast cells. Results are published in Nanotechnology.

PROVIDENCE, R.I. [Brown University] — One in eight women in the United States will develop breast cancer. Of those, many will undergo surgery to remove the tumor and will require some kind of breast reconstruction afterward, often involving implants. Cancer is an elusive target, though, and malignant cells return for as many as one-fifth of women originally diagnosed, according to the American Cancer Society. (more…)

Radiation Generates Cancer Stem Cells From Less Aggressive Breast Cancer Cells

By Guest PostFebruary 19, 2012Healthbreast cancer, cancer cell, chemotherapy, dna damage, frank pajonk, ibcsc, induced pluripotent stem cells, ips, kim irwin, oncologist, radiation therapy, radiation treatment, regenerative medicine, stem cell, tumor, tumor recurrence

Breast cancer stem cells, thought to be the sole source of tumor recurrence, are known to be resistant to radiation therapy and don’t respond well to chemotherapy.

Now, researchers with the UCLA Department of Radiation Oncology at UCLA’s Jonsson Comprehensive Cancer Center report for the first time that radiation treatment, despite killing half of all tumor cells during every treatment, transforms other cancer cells into treatment-resistant breast cancer stem cells. (more…)

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