Dr. Alfredo Quiñones-Hinojosa may not be able to cure his patients’ brain cancer, but there is one thing that the internationally renowned neurosurgeon and neuroscientist can provide them with: hope.
During a recent visit to campus Quiñones-Hinojosa discussed his journey from a migrant farm worker to a doctor who researches the deadliest form of brain cancer, glioblastomas. His talk was sponsored by La Casa Cultural Center, the Latino Cultural Center at Yale. (more…)
People who received frequent dental X-rays in the past, before dosages were lowered, have an increased risk of developing a meningioma, the most common and potentially debilitating type of non-cancerous brain tumor, a new study led by the Yale School of Public Health has found. The study is published online in Cancer, a journal of the American Cancer Society.
Meningioma is listed as a rare disease by the National Institutes of Health. The estimated incidence is up to 8 out of 100,000 people, and it occurs more frequently among women than men. Although it is the most frequently diagnosed type of brain tumor, meningioma is listed as a rare disease by the National Institutes of Health. Tumors develop in a membrane that envelops the brain and the central nervous system known as the meninges. They can grow undetected for years and eventually reach the size of a baseball or larger. While they are not cancerous, they can cause debilitating side effects such as headaches, vision problems, and loss of speech and motor control. (more…)
*Researchers have created a living 3-D model of a brain tumor and its surrounding blood vessels. In experiments, the scientists report that iron-oxide nanoparticles carrying the agent tumstatin were taken by blood vessels, meaning they should block blood vessel growth. The living-tissue model could be used to test the effectiveness of nanoparticles in fighting other diseases. Results appear in Theranostics.*
PROVIDENCE, R.I. [Brown University] — Brown University scientists have created the first three-dimensional living tissue model, complete with surrounding blood vessels, to analyze the effectiveness of therapeutics to combat brain tumors. The 3-D model gives medical researchers more and better information than Petri dish tissue cultures.
The researchers created a glioma, or brain tumor, and the network of blood vessels that surrounds it. In a series of experiments, the team showed that iron-oxide nanoparticles ferrying the chemical tumstatin penetrated the blood vessels that sustain the tumor with oxygen and nutrients. The iron-oxide nanoparticles are important, because they are readily taken up by endothelial cells and can be tracked by magnetic resonance imaging. (more…)
*By studying tumor cell behavior in a novel “scaffold-free” 3-D system, researchers have determined that the protein Pannexin1 may play an important biomechanical role in binding tissues together, an effect that is lost in cancerous cells.*
PROVIDENCE, R.I. [Brown University] — First there is the tumor and then there’s the horrible question of whether the cancerous cells will spread. Scientists increasingly believe that the structural properties of the tumor itself, such as how tightly the tumor cells are packed together, play a decisive role in the progression of the disease. In a new study, researchers show that the protein Pannexin1, known to have tumor-suppressive properties, plays an important role in keeping the cells within a tissue closely packed together, an effect that may be lost with cancer.
“In healthy tissues, the recently discovered protein Pannexin1 may be playing an important role in upholding the mechanical integrity of the tissue,” said first author and Brown University M.D./Ph.D. student Brian Bao. “When we develop cancer, we lose Pannexin1 and we lose this integrity.” (more…)
