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Researchers Make Living Model of Brain Tumor

By Guest PostFebruary 20, 2012Science3 d characteristics, 3 d model, 3d glioma model, agarose hydrogel mold, anti therapeutic agent, aruna sigdel, blood vessel, brain tumor, brown university, chenjie xu, concept, diameter, diffusion, don ho, endothelial cell, glioma, iron oxide nanoparticles, jeffrey morgan, magnetic resonance imaging, microns, microtissues, nanocarrier, nathan kohler, petri dish, raghu kalluri, rat, rg2 cell gliomas, richard lewis, shouheng sun, tissue culture, tissue model, tumstatin

*Researchers have created a living 3-D model of a brain tumor and its surrounding blood vessels. In experiments, the scientists report that iron-oxide nanoparticles carrying the agent tumstatin were taken by blood vessels, meaning they should block blood vessel growth. The living-tissue model could be used to test the effectiveness of nanoparticles in fighting other diseases. Results appear in Theranostics.*

PROVIDENCE, R.I. [Brown University] — Brown University scientists have created the first three-dimensional living tissue model, complete with surrounding blood vessels, to analyze the effectiveness of therapeutics to combat brain tumors. The 3-D model gives medical researchers more and better information than Petri dish tissue cultures.

The researchers created a glioma, or brain tumor, and the network of blood vessels that surrounds it. In a series of experiments, the team showed that iron-oxide nanoparticles ferrying the chemical tumstatin penetrated the blood vessels that sustain the tumor with oxygen and nutrients. The iron-oxide nanoparticles are important, because they are readily taken up by endothelial cells and can be tracked by magnetic resonance imaging. (more…)

Facebook Helps Researchers See How Friendships Form

By Guest PostDecember 21, 2011Culture, Technologyadvertising, basic building blocks, classical, diffusion, emotional health, Facebook, friends, friendship, harvard university, influence, internet, internet and society, internet relationships, jason kaufman, jazz, kevin lewis, marco gonzalez, mechanisms, national science foundation, network, obesity, online social network, patterns of social segregation, relationships, reproduction of inequality, role, society, sociologists, statistical methods

*Long-term study analyzes social selection and peer influence in online environments*

New research funded by the National Science Foundation and published this week in the Proceedings of the National Academy of Sciences by three Harvard University sociologists examines how we select our friends and the role that friendship plays in transmitting tastes and new ideas.

Relationships are basic building blocks of society, and understanding who befriends whom can therefore provide insight into patterns of social segregation, mechanisms for the reproduction of inequality, social support (including mental and emotional health), and access to job opportunities. Some have even viewed these relationships as a means to influence behavior whether to control obesity or target advertising. But is it really that easy, even on the Internet, to make friends with people who have different cultural upbringings, different interests, different backgrounds and different tastes in movies, music and books? (more…)

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Researchers Make Living Model of Brain Tumor

Facebook Helps Researchers See How Friendships Form