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Transactional Memory: An Idea Ahead of Its Time

Nearly 20 years ago, two Brown University computer scientists were working on a largely theoretical problem: How could multiple parallel processors make changes to shared resources safely and efficiently? Their proposal — transactional memory — is sparking fresh interest as a new generation of processors seeks improved power and speed.

In 1993, Maurice Herlihy and a colleague published a paper on transactional memory — a new, clever tactic in computing to deal with handling shared revisions to information seamlessly and concurrently. Few noticed.

Nearly 20 years later, transactional memory is an idea that’s now the rage in hardware computing, and Herlihy, computer science professor at Brown University, has morphed into a prophet of sorts, a computing pioneer who was far ahead of his time. Intel recently announced that transactional memory will be included in its mainstream “Haswell” hardware architecture by next year. IBM has adopted transactional memory in the Blue Gene/Q supercomputer. The original paper by Herlihy and Eliot Moss has been cited more than 1,300 times. (more…)

Researchers Make Living Model of Brain Tumor

By Guest PostFebruary 20, 2012Science3 d characteristics, 3 d model, 3d glioma model, agarose hydrogel mold, anti therapeutic agent, aruna sigdel, blood vessel, brain tumor, brown university, chenjie xu, concept, diameter, diffusion, don ho, endothelial cell, glioma, iron oxide nanoparticles, jeffrey morgan, magnetic resonance imaging, microns, microtissues, nanocarrier, nathan kohler, petri dish, raghu kalluri, rat, rg2 cell gliomas, richard lewis, shouheng sun, tissue culture, tissue model, tumstatin

*Researchers have created a living 3-D model of a brain tumor and its surrounding blood vessels. In experiments, the scientists report that iron-oxide nanoparticles carrying the agent tumstatin were taken by blood vessels, meaning they should block blood vessel growth. The living-tissue model could be used to test the effectiveness of nanoparticles in fighting other diseases. Results appear in Theranostics.*

PROVIDENCE, R.I. [Brown University] — Brown University scientists have created the first three-dimensional living tissue model, complete with surrounding blood vessels, to analyze the effectiveness of therapeutics to combat brain tumors. The 3-D model gives medical researchers more and better information than Petri dish tissue cultures.

The researchers created a glioma, or brain tumor, and the network of blood vessels that surrounds it. In a series of experiments, the team showed that iron-oxide nanoparticles ferrying the chemical tumstatin penetrated the blood vessels that sustain the tumor with oxygen and nutrients. The iron-oxide nanoparticles are important, because they are readily taken up by endothelial cells and can be tracked by magnetic resonance imaging. (more…)

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Transactional Memory: An Idea Ahead of Its Time

Researchers Make Living Model of Brain Tumor