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Radiation Generates Cancer Stem Cells From Less Aggressive Breast Cancer Cells

Breast cancer stem cells, thought to be the sole source of tumor recurrence, are known to be resistant to radiation therapy and don’t respond well to chemotherapy.

Now, researchers with the UCLA Department of Radiation Oncology at UCLA’s Jonsson Comprehensive Cancer Center report for the first time that radiation treatment, despite killing half of all tumor cells during every treatment, transforms other cancer cells into treatment-resistant breast cancer stem cells. (more…)

Scientists Use Animal-Free Reagents to Create Clinical-Grade Neurons from Skin Cells

By Guest PostDecember 11, 2011Scienceanimal based reagents, clinical grade cells, clinical use, derivation and differentiation techniques, embryonic stem cells, gmp, good manufacturing practices, human skin cells, human use, humans, induced pluripotent stem, ips, kim irwin, mouse feeder cells, neural precursor cells, neurons, pluripotent stem cells, process, protocols, saravanan karumbayaram, stem cell, ucla, william lowry

Using a specially designed facility, UCLA stem cell scientists have taken human skin cells, reprogrammed them into cells with the same unlimited property as embryonic stem cells, and then differentiated them into neurons while completely avoiding the use of animal-based reagents and feeder conditions throughout the process.

Generally, stem cells are grown using mouse “feeder” cells, which help the stem cells flourish and grow. But such animal-based products can lead to unwanted variations and contamination, and the cells must be thoroughly tested before they can be deemed safe for use in humans. (more…)

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Radiation Generates Cancer Stem Cells From Less Aggressive Breast Cancer Cells

Scientists Use Animal-Free Reagents to Create Clinical-Grade Neurons from Skin Cells