Tag Archives: genetic tools

From flounders to seahorses: Evolutionary success of spiny-rayed fishes detailed

Even as the dinosaurs were becoming extinct 66 million years ago, the ancient ancestor of spiny-rayed fishes flourished, eventually giving rise to tens of thousands of species that can now be found in home aquariums or on dinner plates. Using modern genetic tools and information from the fossil record, a team led by researchers at Yale University, University of Oxford, and University of California-Davis have constructed a detailed evolutionary history of the 18,000 species of spiny-rayed fishes existing today, a diverse group that includes basses, pufferfishes, and cichlids, and that comprises a large portion of the vertebrate tree of life.

The findings published the week of July 15 in the Proceedings of the National Academy of Sciences show surprisingly close evolutionary relationships between lineages of fish species such as tunas and seahorses, and suggest some fish lineages — like cichlids, the tiny gobies, and little-studied snailfishes — are experiencing high rates of new species origination. (more…)

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Lack of Protein Sp2 Disrupts Neuron Creation in Brain

A protein known as Sp2 is key to the proper creation of neurons from stem cells, according to researchers at North Carolina State University. Understanding how this protein works could enable scientists to “program” stem cells for regeneration, which has implications for neural therapies.

Troy Ghashghaei and Jon Horowitz, both faculty in NC State’s Department of Molecular Biomedical Sciences and researchers in the Center for Comparative Medicine and Translational Research, wanted to know more about the function of Sp2, a cell cycle regulator that helps control how cells divide. Previous research from Horowitz had shown that too much Sp2 in skin-producing stem cells resulted in tumors in experimental mice. Excessive amounts of Sp2 prevented the stem cells from creating normal cell “offspring,” or skin cells. Instead, the stem cells just kept producing more stem cells, which led to tumor formation. (more…)

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