First-of-its-kind study finds gene variant linked to the symptom in menopausal women
Most women experience hot flashes and night sweats either before or during menopause, but a significant minority don’t have these symptoms. Could our genes be a factor in determining which women get hot flashes? (more…)
Scientists have created a molecular map that pinpoints genetic variants that play a role in 21 different autoimmune diseases, they report Oct. 27 in the journal Nature.
Researchers at Yale, the University of California-San Francisco (UCSF), and the Broad Institute of MIT and Harvard developed a sophisticated mathematical model and created maps of different cell types that together enabled them to identify which variants cause the immune response to go awry and cause specific diseases. (more…)
New Bedford Harbor pollution prompts PCB-resistance in Atlantic killifish
For four decades, waste from nearby manufacturing plants flowed into the waters of New Bedford Harbor—an 18,000-acre estuary and busy seaport. The harbor, which is contaminated with polychlorinated biphenyls (PCBs) and heavy metals, is one of the EPA’s largest Superfund cleanup sites.
It’s also the site of an evolutionary puzzle that researchers at Woods Hole Oceanographic Institution (WHOI) and their colleagues have been working to solve. (more…)
*Bacterial cells have gene mutations that allow them to ‘stick’ to the devices*
New research suggests that some patients develop a potentially deadly blood infection from their implanted cardiac devices because bacterial cells in their bodies have gene mutations that allow them to stick to the devices.
Geoscientists were the major contributors to the finding.
Proceedings of the National Academy of Sciences published the study results online this week. (more…)
A genome-wide association study published in the August issue of Nature Medicine has found two tiny genetic variations that can predict which patients with Hodgkin’s lymphoma are most likely to develop radiation-induced second cancers years after treatment. Knowing in advance who is at risk could help physicians tailor treatment to reduce the risks for patients who are most susceptible to long-term damage.
Hodgkin’s lymphoma is one of the most treatable cancers, with more than 90 percent of patients surviving after a combination of radiation and chemotherapy. But nearly 20 percent of patients treated as children develop a second cancer within 30 years. The younger the patients are when treated and the higher the radiation dose, the greater the risk. This late side effect of treatment is the second leading cause of death for long-term Hodgkin’s survivors. (more…)
