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Algorithms find genetic cancer networks

Researchers at Washington University in St., Louis, using powerful algorithms developed by computer scientists at Brown University, have assembled the most complete genetic profile yet of acute myeloid leukemia, an aggressive form of blood cancer. Findings are reported in the New England Journal of Medicine.

PROVIDENCE, R.I. [Brown University] — Powerful data-sifting algorithms developed by computer scientists at Brown University are helping to untangle the profoundly complex genetics of cancer.

In a study reported on May 1, 2013, in the New England Journal of Medicine, researchers from Washington University in St. Louis used two algorithms developed at Brown to assemble the most complete genetic profile yet of acute myeloid leukemia (AML), an aggressive form of blood cancer. The researchers hope the work will lead to new AML treatments based on the genetics of each patient’s disease. (more…)

Two Genetic Variations Predict Second Cancers after Radiation Treatment for Children with Hodgkin’s

By Guest PostJuly 28, 2011Health, Scienceandrew skol, apoptosis, cancer types, cells, differentiation, fundamental cellular processes, gene, genetic variations, hodgkins lymphoma, hodgkins survivors, kenan onel, nature medicine, prdm1, prmd1 gene, proliferation, radiation and chemotherapy, radiation induced second cancers, radiation therapy, sarah jackson, single nucleotide polymorphisms, timothy best, treatable cancers

A genome-wide association study published in the August issue of Nature Medicine has found two tiny genetic variations that can predict which patients with Hodgkin’s lymphoma are most likely to develop radiation-induced second cancers years after treatment. Knowing in advance who is at risk could help physicians tailor treatment to reduce the risks for patients who are most susceptible to long-term damage.

Hodgkin’s lymphoma is one of the most treatable cancers, with more than 90 percent of patients surviving after a combination of radiation and chemotherapy. But nearly 20 percent of patients treated as children develop a second cancer within 30 years. The younger the patients are when treated and the higher the radiation dose, the greater the risk. This late side effect of treatment is the second leading cause of death for long-term Hodgkin’s survivors. (more…)

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Algorithms find genetic cancer networks

Two Genetic Variations Predict Second Cancers after Radiation Treatment for Children with Hodgkin’s