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UW work contributes to largest international study of Alzheimer’s genes

By Guest PostOctober 31, 2013Healthalzheimer's disease, alzheimers genes, amyloid precursor protein, annette fitzpatrick, autoimmune disorder, brain cell, bruce psaty, cell migration, cognitive decline, debby tsuang, gene, genomics of alzheimer, inflammation, international study, joshua bis, lipid transport, multiple sclerosis, neurodegenerative disease, paul k crane, tau protein

Eleven regions of the human genome have been newly discovered to influence the onset of Alzheimer’s disease. The findings stem from the largest international study ever conducted on this disorder, which causes gradual memory loss and other forms of cognitive decline in older people.

As of 2009, 10 genes were known to be related to Alzheimer’s, the result of about a quarter-century of research. Yet the reasons behind individual susceptibility or resistance to the disease continued to be poorly understood. In February of 2011, four international research groups studying Alzheimer’s disease genetics united to more quickly identify other genes related to the disorder. (more…)

Exercise reorganizes the brain to be more resilient to stress

By Guest PostJuly 10, 2013Healthbrain, brain cell, brain region, brian hsueh, elizabeth gould, exercise, fight, flight, gaba, gamma aminobutyric acid, human anxiety disorders, immediate early genes, mechanism, neurons, neurotransmitter, normal brain function, pedro pieruzzini, pedro rada, physical activity, princeton university, reaction, regulate anxiety, resilient to stress, sedentary mice, stanford university, timothy schoenfeld, university of los andes, Venezuela, ventral hippocampus

Physical activity reorganizes the brain so that its response to stress is reduced and anxiety is less likely to interfere with normal brain function, according to a research team based at Princeton University.

The researchers report in the Journal of Neuroscience that when mice allowed to exercise regularly experienced a stressor — exposure to cold water — their brains exhibited a spike in the activity of neurons that shut off excitement in the ventral hippocampus, a brain region shown to regulate anxiety. (more…)

Scientists from UCLA, Israel’s Technion Uncover Brain’s Code for Pronouncing Vowels

By Guest PostAugust 23, 2012Health, Scienceariel tankus, brain, brain cell, device, disease, electrode, frontal lobe, injury, institute of technology, Israel, itzhak fried, nature communication, neuro prosthetic, neurons, paralyze, single cell, speech, technion, temporal gyrus, ucla, unspoken word, vowel, vowel articulation

Discovery may hold key to restoring speech after paralysis

Diagnosed with Lou Gehrig’s disease at 21, British physicist Stephen Hawking, now 70, relies on a computerized device to speak. Engineers are investigating the use of brainwaves to create a new form of communication for Hawking and other people suffering from paralysis.

—Daily Mail (U.K.)

Scientists at UCLA and the Technion, Israel’s Institute of Technology, have unraveled how our brain cells encode the pronunciation of individual vowels in speech.

Published in the Aug. 21 edition of the journal Nature Communications, the discovery could lead to new technology that verbalizes the unspoken words of people paralyzed by injury or disease. (more…)

Yale Team Discovers How Stress and Depression Can Shrink the Brain

By Guest PostAugust 20, 2012Health, Scienceanimal model, antidepressant therapy, ashley lepack, bhavya voleti, brain, brain cell, brain mass, brain volume, chronic stress, cognitive impairment, depression, emotional, gata1, gene, gene activation, genetic switch, h j kang, mounira banasr, pattern, pawel licznerski, prefrontal cortex, ronald duman, shrink, stress, symptoms of depression, synaptic connection, transcription factor, yale

Major depression or chronic stress can cause the loss of brain volume, a condition that contributes to both emotional and cognitive impairment. Now a team of researchers led by Yale scientists has discovered one reason why this occurs — a single genetic switch that triggers loss of brain connections in humans and depression in animal models.

The findings, reported in the Aug. 12 issue of the journal Nature Medicine, show that the genetic switch known as a transcription factor represses the expression of several genes that are necessary for the formation of synaptic connections between brain cells, which in turn could contribute to loss of brain mass in the prefrontal cortex. (more…)

Common Parasite May Trigger Suicide Attempts

By Guest PostAugust 18, 2012Health, Scienceamerica, biological change, biological mechanism, brain, brain cell, damage, depression, harmless, infection, inflammation, lena brundin, parasite, parkinsons disease, suicide attempt, symptom, t gondii, teodor postolache, toxoplasma gondii, united states

EAST LANSING, Mich. — A parasite thought to be harmless and found in many people may actually be causing subtle changes in the brain, leading to suicide attempts.

New research appearing in the August issue of The Journal of Clinical Psychiatry adds to the growing work linking an infection caused by the Toxoplasma gondii parasite to suicide attempts. Michigan State University’s Lena Brundin was one of the lead researchers on the team.

About 10-20 percent of people in the United States have Toxoplasma gondii, or T. gondii, in their bodies, but in most it was thought to lie dormant, said Brundin, an associate professor of experimental psychiatry in MSU’s College of Human Medicine. In fact, it appears the parasite can cause inflammation over time, which produces harmful metabolites that can damage brain cells. (more…)

Distinct Brain Cells Recognize Novel Sights

By Guest PostApril 16, 2012Sciencebrain area, brain cell, brown university, cell type, david orenstein, david sheinberg, excitatory neuron, inferior temporal cortex, itc, luke woloszyn, novel sight, plasticity, repair circuit, skull, traumatic brain injury

The brain’s ability to learn to recognize objects plays out in the inferior temporal cortex. A new study offers a possible explanation of how two classes of neurons play distinct roles to help that happen.

PROVIDENCE, R.I. [Brown University] — No matter what novel objects we come to behold, our brains effortlessly take us from an initial “What’s that?” to “Oh, that old thing” after a few casual encounters. In research that helps shed light on the malleability of this recognition process, Brown University neuroscientists have teased apart the potentially different roles that two distinct cell types may play.

In a study published online in advance in the journal Neuron, the researchers document that this kind of learning is based in the inferior temporal cortex (ITC), a brain area buried deep in the skull. Scientists already knew the area was important for visual recognition of familiar items, but they hadn’t figured out the steps required to move from novelty to familiarity, a process they refer to as “plasticity.” (more…)

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