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How a Microbial Biorefinery Regulates Genes

By Guest PostMarch 1, 2013Sciencealternatives to petroleum, amino acid, aromatic compounds, biomass, biorefinery, breann brown, brown university, consumption of lignin, depolymerize, digesting lignin, DNA, dna binding activity, enzyme, gene expression, genes, high value chemicals, jason sello, jennifer davis, kind of protein, lignin, marr family, microbial biorefinery, microorganisms, pcav, pcav dna complex, phenomenon, plant biomass, protein crystallography, protocatechuate, rebecca page, streptomyces bacteria, technique, Technology, transcription factor, variety of biofuels

Digesting lignin, a highly stable polymer that accounts for up to a third of biomass, is a limiting step to producing a variety of biofuels. Researchers at Brown have figured out the microscopic chemical switch that allows Streptomyces bacteria to get to work, breaking lignin down into its constituent parts.

PROVIDENCE, R.I. [Brown University] — Microorganisms that can break down plant biomass into the precursors of biodiesel or other commodity chemicals might one day be used to produce alternatives to petroleum. But the potential of this “biorefinery” technology is limited by the fact that most microorganisms cannot break down lignin, a highly stable polymer that makes up as much as a third of plant biomass.

Streptomyces bacteria are among few microorganisms known to degrade and consume lignin. Now a group of researchers at Brown University has unlocked the genetic and molecular mechanisms behind a key part of that process. The results are published in the journal Nucleic Acids Research. (more…)

Yale Team Discovers How Stress and Depression Can Shrink the Brain

By Guest PostAugust 20, 2012Health, Scienceanimal model, antidepressant therapy, ashley lepack, bhavya voleti, brain, brain cell, brain mass, brain volume, chronic stress, cognitive impairment, depression, emotional, gata1, gene, gene activation, genetic switch, h j kang, mounira banasr, pattern, pawel licznerski, prefrontal cortex, ronald duman, shrink, stress, symptoms of depression, synaptic connection, transcription factor, yale

Major depression or chronic stress can cause the loss of brain volume, a condition that contributes to both emotional and cognitive impairment. Now a team of researchers led by Yale scientists has discovered one reason why this occurs — a single genetic switch that triggers loss of brain connections in humans and depression in animal models.

The findings, reported in the Aug. 12 issue of the journal Nature Medicine, show that the genetic switch known as a transcription factor represses the expression of several genes that are necessary for the formation of synaptic connections between brain cells, which in turn could contribute to loss of brain mass in the prefrontal cortex. (more…)

Chemical in Spice Turmeric Kickstarts Cancer-Killing Mechanisms in Human Saliva

By Guest PostSeptember 18, 2011Health, Scienceanti aging agent, anti inflammatory effects, cancer enhancing cytokines, curcumin, enzyme, eri srivatsan, head and neck cancer, hpv virus, human saliva, ikk, India, kappa β kinase, marilene wang, medicinal properties, menstrual cramps, nfκβ, not toxic, nuclear factor kappa β, oral cancers, poultice, pro inflammatory cytokines, signaling molecules, south asian and middle eastern cooking, spice turmeric, transcription factor, turmeric, wound healing

Curcumin, the main component in the spice turmeric, suppresses a cell signaling pathway that drives the growth of head and neck cancer, according to a pilot study using human saliva by researchers at UCLA’s Jonsson Comprehensive Cancer Center.

The inhibition of the pathway also correlated with reduced expression of a number of pro-inflammatory cytokines, or signaling molecules, in the saliva that promote cancer growth, said senior study author Dr. Marilene Wang, a professor of head and neck surgery and a Jonsson Cancer Center researcher. (more…)

Tag Archives: transcription factor

How a Microbial Biorefinery Regulates Genes

Yale Team Discovers How Stress and Depression Can Shrink the Brain

Chemical in Spice Turmeric Kickstarts Cancer-Killing Mechanisms in Human Saliva