ANN ARBOR—A banana a day may not keep the doctor away, but a substance originally found in bananas and carefully edited by scientists could someday fight off a wide range of viruses, new research suggests. (more…)
Imagine that an invisible, microscopic invader has found its way into your body and hijacked the cellular machinery that keeps you healthy. Inhabiting the gray area between living and nonliving, the invader can only reproduce once it makes its new home inside of your cells, eventually causing you to fall ill. How do physicians and scientists combat this uninvited guest? (more…)
Researchers at UD use ancient gene to study virus biology
Researchers at the University of Delaware have discovered that an ancient gene — ribonucleotide reductase (RNR), which occurs in all cellular life — provides important biological insights into the characteristics of unknown viruses in the sea. (more…)
Knowing the temperatures that viruses, bacteria, worms and all other parasites need to grow and survive could help determine the future range of infectious diseases under climate change, according to new research.
Princeton University researchers developed a model that can identify the prospects for nearly any disease-causing parasite as the Earth grows warmer, even if little is known about the organism. Their method calculates how the projected temperature change for an area would alter the creature’s metabolism and life cycle, the researchers report in the journal Ecology Letters. (more…)
*Proprotein convertases are enzymes that activate many essential proteins, but they are also implicated in many processes that cause disease. In a research review in the New England Journal of Medicine, Andrew Artenstein and Steven Opal argue that proprotein convertases are potentially rich targets for developing therapies.*
Most people have never heard of proprotein convertases, but the enzymes activate many proteins that are essential for life. Unfortunately, their fundamental role puts them in the middle of many processes that cause disease – not just cancer or athlerosclerosis, but both of those and Alzheimer’s and anthrax and the flu and an amazing variety of other maladies.
In a research review article appearing Dec. 29 in the New England Journal of Medicine, Andrew Artenstein, physician-in-chief in the Department of Medicine at Memorial Hospital, and Steven Opal, chief of infectious diseases at Memorial Hospital, argue that proprotein convertases (PCs) are potentially rich targets for developing therapies. Artenstein, who with Opal is on the faculty of the Warren Alpert School of Medicine, explained PCs to David Orenstein. (more…)
*Looking in vivo at virus-bacterium associations sets stage for better understanding of such interactions in human health*
Viruses are the most abundant parasites on Earth. Well known viruses, such as the flu virus, attack human hosts, while viruses such as the tobacco mosaic virus infect plant hosts.
More common, but less understood, are cases of viruses infecting bacteria known as bacteriophages, or phages. In part, this is due to the difficulty of culturing bacteria and viruses that have been cut off from their usual biological surroundings in a process called in vitro. (more…)
