Findings could lead to treatments for blood disorders associated with both iron deficiencies and overloads
A UCLA research team has discovered a new hormone called erythroferrone, which regulates the iron supply needed for red blood-cell production.
Iron is an essential functional component of hemoglobin, the molecule that transports oxygen throughout the body. Using a mouse model, researchers found that erythroferrone is made by red blood-cell progenitors in the bone marrow in order to match iron supply with the demands of red blood-cell production. Erythroferrone is greatly increased when red blood-cell production is stimulated, such as after bleeding or in response to anemia. (more…)