Tag Archives: bone marrow

Researchers discover hormone that controls supply of iron in red blood cell production

Findings could lead to treatments for blood disorders associated with both iron deficiencies and overloads

A UCLA research team has discovered a new hormone called erythroferrone, which regulates the iron supply needed for red blood-cell production.

Iron is an essential functional component of hemoglobin, the molecule that transports oxygen throughout the body. Using a mouse model, researchers found that erythroferrone is made by red blood-cell progenitors in the bone marrow in order to match iron supply with the demands of red blood-cell production. Erythroferrone is greatly increased when red blood-cell production is stimulated, such as after bleeding or in response to anemia. (more…)

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Marrow microenvironment

Research provides new insights into bone biology

Bone marrow, the spongy tissue inside long bones, produces new blood cells and helps the lymphatic system work properly.  But it may also turn out to be a progressively hostile microenvironment that induces vascular dysfunction and ossification, or hardening, of blood vessels.

Rhonda Prisby, who is using a rat model to study bone vascular physiology and morphology, was recently surprised when she used light microscopy to look at bone marrow vessels. (more…)

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Immune Systems of ‘Bubble Babies’ Restored by Gene Therapy, UCLA Researchers Find

UCLA stem cell researchers have found that a gene therapy regimen can safely restore immune systems to children with so-called “bubble boy” disease, a life-threatening condition that if left untreated can be fatal within one to two years.

In the 11-year study, researchers were able to test two therapy regimens for 10 children with ADA-deficient severe combined immunodeficiency (SCID), which has come to be known as “bubble boy” disease because some of its victims have been forced to live in sterile environments. (more…)

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UCLA Scientists Discover ‘Missing Link’ Between Blood Stem Cells, Immune System

UCLA researchers have discovered a type of cell that is the “missing link” between bone marrow stem cells and all the cells of the human immune system, a finding that will lead to a greater understanding of how a healthy immune system is produced and how disease can lead to poor immune function.

The research was done using human bone marrow, which contains all the stem cells that produce blood during post-natal life. (more…)

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Rebuilding a Heart, Saving a Life

A young girl in Bridgeport, Connecticut, born with one of the most serious, life-threatening congenital heart defects known, is on her way to living a normal life thanks to Yale doctors who developed and performed the first operation of its kind in the United States.

Angela Irizarry was the first American patient to receive a tissue-engineered blood vessel made of her own natural cells. (more…)

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UCLA Scientists ID Cell, Signaling Pathway That Regulate Blood Stem Cells in Placenta

UCLA stem-cell researchers have identified a certain type of cell and a signaling pathway in the placental niche that play a key role in stopping blood stem cells from differentiating into mature blood cells in the placenta. Preventing this premature differentiation is critical to ensuring a proper blood supply for an individual’s lifetime.

The placental niche is considered a stem cell “safe zone,” which supports the creation and expansion of blood stem cells without promoting their differentiation into mature cells. This allows for the establishment of a pool of precursor cells that will later provide blood cells for fetal and post-natal life, said the study’s senior author, Dr. Hanna Mikkola, an associate professor of molecular cell and developmental biology at UCLA and a researcher at UCLA’s Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research. (more…)

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Researchers See a ‘Picture’ of Threat in The Brain: Work May Lead to New Model of Inflammation

COLUMBUS, Ohio – A team of researchers is beginning to see exactly what the response to threats looks like in the brain at the cellular and molecular levels.

This new information, including the discovery that a model of social stress can increase inflammation among brain cells, should provide new insight into how the stress response affects inflammatory and behavioral responses. (more…)

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Mandi Schwartz Update: Tests Indicate Birth of New Immune System

Mandi Schwartz. Image credit: Yale University

After spending six days in intensive care fighting her way through another life-threatening condition, Yale hockey player Mandi Schwartz got some much-needed positive news in her battle with cancer on Friday.

Tests have confirmed that, 23 days after her stem cell transplant, engraftment — i.e., the birth of her new immune system — has taken place. This marks a major positive step, but challenges still remain for the Yale women’s ice hockey center. (more…)

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