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Researchers discover hormone that controls supply of iron in red blood cell production

By Guest PostJuly 18, 2014Healthbone marrow, control, failure behavior, fairness, fake news, level of rigidity, material failure, media propaganda, production, red blood cell, sibylle schroer, strassenbeleuchtung, tomas ganz, verlust der nacht, why materials break

Findings could lead to treatments for blood disorders associated with both iron deficiencies and overloads

A UCLA research team has discovered a new hormone called erythroferrone, which regulates the iron supply needed for red blood-cell production.

Iron is an essential functional component of hemoglobin, the molecule that transports oxygen throughout the body. Using a mouse model, researchers found that erythroferrone is made by red blood-cell progenitors in the bone marrow in order to match iron supply with the demands of red blood-cell production. Erythroferrone is greatly increased when red blood-cell production is stimulated, such as after bleeding or in response to anemia. (more…)

Transfusions add Risk in Some Heart Attacks

By Guest PostDecember 27, 2012Healthaabb, abhishek sharma, analyzed data, anemia, blood transfusions, brown university, concentration, debabrata mukherjee, emergency, heart attack, hematocrit, high quality data, jorn wetterslev, liberal transfusions, maimonides medical center, medical factors, meta analysis, new york, patient, randomized trial, red blood cell, risk of death, saurav chatterjee, spectrum, statistical adjustments, texas tech university, treatment, united states, units of blood

A new study published in the Archives of Internal Medicine finds that while blood transfusions for heart attack patients with anemia are commonly performed in emergency rooms, the practice can increase the risk of death when the transfusions are too extensive. The authors, led by Saurav Chatterjee, a cardiology fellow at Brown University, compared evidence from 10 prior studies of more than 203,000 patients.

PROVIDENCE, R.I. [Brown University] — When heart attack patients present in the emergency department with some degree of anemia, or anemic patients have a heart attack, physicians have a tendency, but not much guidance, about whether to provide a blood transfusion. The idea is that a transfusion could help more oxygen get to the heart. Recent national guidelines suggested that there simply isn’t good evidence to encourage or discourage the common practice, but a new meta-analysis of 10 studies involving more than 203,000 such patients comes down on the side of it increasing the risk of death. (more…)

UCLA Scientists Discover ‘Missing Link’ Between Blood Stem Cells, Immune System

By Guest PostSeptember 5, 2012Health, Scienceblood, blood lineage, bone marrow, cell, diseases, gay crooks, gene, haystack, human, immune deficiency, immune function, immune system, infection, leukemia, lisa kohn, lymphocytes, missing link, needle, platelets, post natal life, progenitors, red blood cell, researcher, set, stem cell, type, ucla

UCLA researchers have discovered a type of cell that is the “missing link” between bone marrow stem cells and all the cells of the human immune system, a finding that will lead to a greater understanding of how a healthy immune system is produced and how disease can lead to poor immune function.

The research was done using human bone marrow, which contains all the stem cells that produce blood during post-natal life. (more…)

Pigeons’ Homing Skill Not Down to Iron-Rich Beak Cells

By Guest PostApril 16, 2012Natureballs of iron, beaks, david keays, electrical signal, Environment, imaging technique, infection, iron, macrophages, magnetic cell, magnetic field, magnetic nerve cell, mark lythgoe, mechanism, migratory bird, navigation, nerve cell, pigeon, red blood cell, state-of-the-art, theory, university college london, vienna, white blood cell

The theory that pigeons’ famous skill at navigation is down to iron-rich nerve cells in their beaks has been disproved by a new study published in Nature.

The study shows that iron-rich cells in the pigeon beak are in fact specialised white blood cells, called macrophages. This finding, which shatters the established dogma, puts the field back on course as the search for magnetic cells continues. (more…)

UCLA Scientists ID Cell, Signaling Pathway That Regulate Blood Stem Cells in Placenta

By Guest PostMarch 2, 2012Scienceakanksha chhabra, blood cells, blood stem cells, bone marrow, cell, cytokine, epo, erythropoietin, hanna mikkola, kim irwin, mother and fetus, mouse models, pdgf b, placenta, post natal life, protein molecule, red blood cell, safe zone, stem cell, trophoblasts, ucla, undifferentiated state

UCLA stem-cell researchers have identified a certain type of cell and a signaling pathway in the placental niche that play a key role in stopping blood stem cells from differentiating into mature blood cells in the placenta. Preventing this premature differentiation is critical to ensuring a proper blood supply for an individual’s lifetime.

The placental niche is considered a stem cell “safe zone,” which supports the creation and expansion of blood stem cells without promoting their differentiation into mature cells. This allows for the establishment of a pool of precursor cells that will later provide blood cells for fetal and post-natal life, said the study’s senior author, Dr. Hanna Mikkola, an associate professor of molecular cell and developmental biology at UCLA and a researcher at UCLA’s Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research. (more…)

Tag Archives: red blood cell

Researchers discover hormone that controls supply of iron in red blood cell production

Transfusions add Risk in Some Heart Attacks

UCLA Scientists Discover ‘Missing Link’ Between Blood Stem Cells, Immune System

Pigeons’ Homing Skill Not Down to Iron-Rich Beak Cells

UCLA Scientists ID Cell, Signaling Pathway That Regulate Blood Stem Cells in Placenta