Tag Archives: immunology

UCLA nanoscientists are first to model atomic structures of three bacterial nanomachines

Cryo electron microscope enables scientists to explore the frontiers of targeted antibiotics

Researchers at UCLA’s California NanoSystems Institute have become the first to produce images of the atomic structures of three specific biological nanomachines, each derived from a different potentially deadly bacterium — an achievement they hope will lead to antibiotics targeted toward specific pathogens. (more…)

Read More

Newly found tactics in offense-defense struggle with hepatitis C virus

The hepatitis C virus has a previously unrecognized tactic to outwit antiviral responses and sustain a long-term infection. It also turns out that some people are genetically equipped with a strong countermeasure to the virus’ attempt to weaken the attack on it.

The details of these findings suggest potential targets for treating HCV, according to a research team led by Dr. Ram Savan, assistant professor of immunology at the University of Washington. The study was published in Nature Immunology. (more…)

Read More

African Chickens

UD’s Schmidt studies heat stress, disease resistance in African chickens

Last fall, the University of Delaware’s Carl Schmidt took a trip to Uganda with a team of researchers from Iowa State University and North Carolina State University to get genetic samples from African chickens. The goal was to compare and contrast their genes to one another, and also to American broiler chickens, to gauge how the two species’ genetic makeup helps them cope with heat stress, as well as susceptibility and resistance to different diseases.

The trip was part of a five-year, $4.7 million National Institute of Food and Agriculture (NIFA) climate change grant for a project titled “Adapting Chicken Production to Climate Change Through Breeding.” (more…)

Read More

Immune Systems of ‘Bubble Babies’ Restored by Gene Therapy, UCLA Researchers Find

UCLA stem cell researchers have found that a gene therapy regimen can safely restore immune systems to children with so-called “bubble boy” disease, a life-threatening condition that if left untreated can be fatal within one to two years.

In the 11-year study, researchers were able to test two therapy regimens for 10 children with ADA-deficient severe combined immunodeficiency (SCID), which has come to be known as “bubble boy” disease because some of its victims have been forced to live in sterile environments. (more…)

Read More

Tuberculosis Protects Itself Against Toxic Agents Sent to Destroy It

ANN ARBOR, Mich.—Tuberculosis fights off the toxic agents, acidity and oxidants, that our immune system sends to destroy it, which is why the maddeningly drug-resistant bacterium can survive in harsh conditions in our bodies for essentially as long as its human host lives, new research shows. (more…)

Read More