Tag Archives: acute

‘Map of pain’ reveals how our ability to identify the source of pain varies across the body

“Where does it hurt?” is the first question asked to any person in pain.

A new UCL study defines for the first time how our ability to identify where it hurts, called “spatial acuity”, varies across the body, being most sensitive at the forehead and fingertips.

Using lasers to cause pain to 26 healthy volunteers without any touch, the researchers produced the first systematic map of how acuity for pain is distributed across the body. The experiment, conducted in the group led by Dr Giandomenico Iannetti (UCL Neuroscience, Physiology and Pharmacology), is published in the journal Annals of Neurology and was funded by the Wellcome Trust. (more…)

Read More

Tactics of new Middle East virus suggest treating by altering lung cells’ response to infection

A new virus that causes severe breathing distress and kidney failure elicits a distinctive airway cell response to allow it to multiply.  Scientists studying the Human Coronavirus-Erasmus Medical Center, which first appeared April 2012 in the Middle East, have discovered helpful details about its stronghold tactics.

Their findings predict that certain currently available compounds might treat the infection.  These could act not by killing the virus directly but by keeping lung cells from being forced to create a hospitable environment for the virus to reproduce.  The researchers caution that their lab and computer predictions would need to be tested to see if the drugs work clinically. (more…)

Read More

Switch off Enzyme to Control Chronic Pain, say U of T Researchers

*New drug shows promise for treating chronic pain*

A team of researchers at the University of Toronto has developed a new drug targeted at parts of the brain and spinal cord associated with pain perception, which may more effectively control chronic pain caused by nerve injuries.

In a paper published Jan. 12 in the journal Science Translational Medicine, a team led by Professor Min Zhuo of the Department of Physiology and Centre for the Study of Pain, the Canada Research Chair in Pain and Cognition, showed that a new drug called NB001 produced powerful pain-killing effects in mice and in human neuronal cell lines. (more…)

Read More