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The Rise of Zika—Another Mosquito Virus in the Americas

By Guest PostMay 3, 2016Healthaedes aegypti, albert ko, americas, diseases, infectious, mosquito virus, rise of zika, scistyle, thomas splettstoesser, zika transmission

Zika, the latest mosquito-borne virus to emerge in the Americas, is rapidly becoming a public health crisis. In Brazil, it is suspected in a sharp increase in microcephaly (a birth defect that results in newborns with smaller than normal head size), leading to anxiety amongst expecting mothers and a travel advisory from the Centers for Disease Control and Prevention. Traditionally, the virus has been fairly benign, causing a rash and a fever that is usually non-life threatening. Professor Albert Ko, chair of the Department of Epidemiology of Microbial Diseases at the Yale School of Public Health, has been working with colleagues in Brazil for months to understand if the virus has changed and what is causing the birth defects in newborns. (more…)

Mystery of the mutant polyomavirus

By Guest PostJuly 7, 2013Health, Scienceaaron derdowski, astrocytes, bethany ohara, brain glial cells, brown university, carbohydrate, crystal structure, DNA, gretchen gee, infectious, jc polyomavirus, lstc, luisa ströh, melissa maginnis, mutant form, mutant polyomavirus, myelin, mystery, non infection, oligodendrocytes, pathogen, pml, progressive multifocal leukoencephalopathy, thilo stehle, university of tübingen, ursula neu, vanderbilt university, virus, walter atwood, wild type, xray crystallography

A new study shows that common mutant forms of the deadly JC polyomavirus are not responsible for the pathogen’s main attack, which causes a brain-damaging disease in immunocompromised patients called progressive multifocal leukoencephalopathy. But that finding raises the ominous question of what the mutants might be up to instead.

PROVIDENCE, R.I. [Brown University] — The JC polyomavirus is clearly opportunistic. It infects half the population but lethally destroys brain tissue only in immunocompromised patients — and it may be outright sneaky, too. Even as a new research paper allays fears that common mutant forms of the virus are the ones directly responsible for the disease’s main attack, that same finding raises new questions about what the mutants are doing instead. (more…)

Bacteria May Signal Pancreatic Cancer Risk

By Guest PostSeptember 25, 2012Healthantibodies, bacterium strain, blood sample, brown university, cancer, carcinogenesis, commensal bacteria, dominique michaud, european adult, forsyth institute, harvard university, immune defense, infectious, jacques izard, lance liotta, marker, oral bacterium, pancreatic cancer, pathogenic bacteria, periodontal disease, porphyromonas gingivalis, risk factor, united states

Pancreatic cancer is highly lethal and difficult to detect early. In a new study, researchers report that people who had high levels of antibodies for an infectious oral bacterium turned out to have double the risk for developing the cancer. High antibody levels for harmless oral bacteria, meanwhile, predicted a reduced pancreatic cancer risk.

PROVIDENCE, R.I. [Brown University] — A new study finds significant associations between antibodies for multiple oral bacteria and the risk of pancreatic cancer, adding support for the emerging idea that the ostensibly distant medical conditions are related.

The study of blood samples from more than 800 European adults, published in the journal Gut, found that high antibody levels for one of the more infectious periodontal bacterium strains of Porphyromonas gingivalis were associated with a two-fold risk for pancreatic cancer. Meanwhile, study subjects with high levels of antibodies for some kinds of harmless “commensal” oral bacteria were associated with a 45-percent lower risk of pancreatic cancer. (more…)

Tag Archives: infectious

The Rise of Zika—Another Mosquito Virus in the Americas

Mystery of the mutant polyomavirus

Bacteria May Signal Pancreatic Cancer Risk