AUSTIN, Texas — Researchers in the Cockrell School of Engineering at The University of Texas at Austin have discovered a correlation between aging and the effectiveness of T-cells, a type of immune cell programmed to fight or kill a threat. The researchers found that older people have T-cells that are less effective at fending off the hepatitis C virus (HCV). (more…)
Tag Archives: aging
Using a recently developed biomarker of aging known as an epigenetic clock, UCLA researchers working closely with a German team of investigators have found for the first time that obesity greatly accelerates aging of the liver. This finding could explain the early onset of many age-related diseases, including liver cancer, in people who are obese. (more…)
Exogen can check the DNA health not only of an individual but that of an entire region, thus answering questions on the impact of environmental events.
Currently if a scientist or doctor wanted to measure the level of a person’s DNA damage, they would have to look at some cells in a fluorescent microscope and manually count the number of DNA breaks. This kind of counting is labor-intensive, time-consuming, and a highly subjective process. Lawrence Berkeley National Laboratory (Berkeley Lab) scientist Sylvain Costes, who has spent over a decade studying the effects of low-dose radiation on cellular processes, came up with a way to automate the job using a proprietary algorithm and a machine to scan specimens and objectively score the damaged DNA. (more…)
UMD-led study is first to link racism-related factors and cellular age
COLLEGE PARK, Md. – A new University of Maryland-led study reveals that racism may impact aging at the cellular level. Researchers found signs of accelerated aging in African American men who reported high levels of racial discrimination and who had internalized anti-Black attitudes. Findings from the study, which is the first to link racism-related factors and biological aging, are published in the American Journal of Preventive Medicine.
Racial disparities in health are well-documented, with African Americans having shorter life expectancy, and a greater likelihood of suffering from aging-related illnesses at younger ages compared to whites. Accelerated aging at the biological level may be one mechanism linking racism and disease risk. (more…)
UA researchers have discovered that two separate defects combine to contribute to reduced T cell responses with aging.
Researchers at the University of Arizona College of Medicine – Tucson have found a key to understanding the aging immune system’s decreased response to infectious diseases, which remain among the leading causes of death in older adults.
Aging profoundly affects the immune system’s T cells – the types of white blood cells that defend against intracellular pathogens, such as viruses, intracellular bacteria or parasites, such as malaria. Newly encountered pathogens are attacked by what are known as naïve T cells, some of which then learn and remember, becoming memory T cells that prevent reinfection when they encounter the same pathogen again. But naïve T cells become depleted with age, leading to less effective immune responses against new infections. (more…)
In yeast at least, the aging process appears to reduce an organism’s ability to silence certain genes that need to be silenced. Now researchers at Brown University who study the biology of aging have shown that the loss of genetic control occurs in fruit flies as well. Results appear online in the journal Aging.
PROVIDENCE, R.I. [Brown University] — Biologists at Brown University have found a way to measure the effects of aging by watching the ebb and flow of chromatin, a structure along strands of DNA that either silences or permits gene expression. In several newly published experiments they show that gene silencing via chromatin in fruit flies declines with age. (more…)
UCLA life scientists have identified a gene previously implicated in Parkinson’s disease that can delay the onset of aging and extend the healthy life span of fruit flies. The research, they say, could have important implications for aging and disease in humans.
The gene, called parkin, serves at least two vital functions: It marks damaged proteins so that cells can discard them before they become toxic, and it is believed to play a key role in the removal of damaged mitochondria from cells. (more…)
Technologically valuable ultrastable glasses can be produced in days or hours with properties corresponding to those that have been aged for thousands of years, computational and laboratory studies have confirmed.
Aging makes for higher quality glassy materials because they have slowly evolved toward a more stable molecular condition. This evolution can take thousands or millions of years, but manufacturers must work faster. Armed with a better understanding of how glasses age and evolve, researchers at the universities of Chicago and Wisconsin-Madison raise the possibility of designing a new class of materials at the molecular level via a vapor-deposition process. (more…)