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Stem Cell Transplants in Mice Produce Lifelong Enhancement of Muscle Mass

By Guest PostNovember 13, 20102 commentsScienceaging, bradley olwin, cell transplant, chronic, degenerative muscle diseases, green fluorescent protein, leg muscles, mice, muscle function, muscle stem cells, myofibers, satellite cells, stem cells, transplant, ultraviolet light, university of colorado at boulder

A University of Colorado at Boulder-led study shows that specific types of stem cells transplanted into the leg muscles of mice prevented the loss of muscle function and mass that normally occurs with aging, a finding with potential uses in treating humans with chronic, degenerative muscle diseases.

The experiments showed that when young host mice with limb muscle injuries were injected with muscle stem cells from young donor mice, the cells not only repaired the injury within days, they caused the treated muscle to double in mass and sustain itself through the lifetime of the transplanted mice. “This was a very exciting and unexpected result,” said Professor Bradley Olwin of CU-Boulder’s molecular, cellular and developmental biology department, the study’s corresponding author. (more…)

New 3-D Model of RNA ‘Core Domain’ of Enzyme Telomerase May Offer Clues to Cancer, Aging

By Guest PostNovember 6, 2010Health, Scienceaging, cancer, cells, chromosomes, DNA, dna damage, enzyme, helical extension, juli feigon, medicine, nmr, nobel prize, nuclear magnetic resonance, physiology, proteins, pseudoknot, qi zhang, rna, spectroscopy, telomerase, telomeres, virus

A model representation of telomerase's RNA "core domain," determined by Juli Feigon, Qi Zhang and colleagues in Feigon's UCLA laboratory. Image credit: Juli Feigon, UCLA Chemistry and Biochemistry/PNAS

Telomerase is an enzyme that maintains the DNA at the ends of our chromosomes, known as telomeres. In the absence of telomerase activity, every time our cells divide, our telomeres get shorter. This is part of the natural aging process, as most cells in the human body do not have much active telomerase. Eventually, these DNA-containing telomeres, which act as protective caps at the ends of chromosomes, become so short that the cells die.

But in some cells, such as cancer cells, telomerase, which is composed of RNA and proteins, is highly active and adds telomere DNA, preventing telomere shortening and extending the life of the cell.

UCLA biochemists have now produced a three-dimensional structural model of the RNA “core domain” of the telomerase enzyme. Because telomerase plays a surprisingly important role in cancer and aging, understanding its structure could lead to new approaches for treating disease, the researchers say. (more…)

Coffee Protects Body from Cancer and Slows Down Aging

By PravdaJune 6, 20104 commentsHealthafrica, African monks, aging, antooxidant, beverage, blood pressure, caffeine, can cer, champagne, coffee, coffee beans, decaf, decaffeination, dichloromethane, erectile dysfunction, ethopian goatherder, green tea, insomnia, kaldi, nervous breakdown, organic solvent, red wine, south west university, tachycardia, tea, university of georgia, vascular wall contract

Here are some facts about coffee:

Fact 1. Coffee can be good for you

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Tag Archives: aging

Stem Cell Transplants in Mice Produce Lifelong Enhancement of Muscle Mass

New 3-D Model of RNA ‘Core Domain’ of Enzyme Telomerase May Offer Clues to Cancer, Aging

Coffee Protects Body from Cancer and Slows Down Aging