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Making Germs Glow: New Test Helps Save Lives and Cuts Costs

By Guest PostOctober 15, 2011Scienceadvandx, beneficial bacteria, bioindustry sponsors, blood cultures, bloodstream infections, clinical microbiology laboratories, dna sequence, donna wolk, fluorescence, genetic code, infectious disease, lag time, microbiology, pathogens, peptide nucleic acid fluorescence in situ hybridization, pna fish

*Replacing conventional laboratory tests with a new DNA sequence-based technology to identify pathogens causing bloodstream infections dramatically lowered mortality and health-care costs, a clinical study conducted by an interdisciplinary UA research team found.*

Unlike conventional laboratory tests, a new technology called PNA-FISH is designed to rapidly identify bloodstream pathogens by their genetic code. Results are available within hours instead of days providing pharmacists and physicians with information they can use to rapidly customize antimicrobial treatment for patients with infections.

PNA-FISH is an abbreviation for “peptide nucleic acid fluorescence in situ hybridization.” Rapid reporting of PNA FISH results to pharmacists and physicians cut the mortality of ICU patients with enterococcus or streptococcus bloodstream infections by almost half and slashed mortality from yeast infections by 86 percent. In addition, the intervention resulted in healthcare cost reduction of almost $5 million per year. (more…)

It Takes a Community of Soil Microbes to Protect Plants From Disease

By Guest PostMay 15, 2011Environment, Scienceactinobacteria, archaea, bacteria, berkeley lab, burkholderia, complex microbial network, coral reefs, deepwater horizon spill, disease, dna sequences, dutch scientists, environmental mysteries, gary andersen, gulf of mexico, immune system, mammals, pathogens, phylochip, plants, potato, psuedomonas, puerto rico, rathmann family foundation, rhizoctonia solani, rice, root fungus, soil, soil microbes, sugar beet, todd desantis, types of bacteria, vegetables, xanthomonas, yvette piceno

*Berkeley Lab scientists decipher immune system for plants beneath our feet*

Those vegetables you had for dinner may have once been protected by an immune system akin to the one that helps you fight disease. Scientists from the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) and the Netherland’s Wageningen University found that plants rely on a complex community of soil microbes to defend themselves against pathogens, much the way mammals harbor a raft of microbes to avoid infections.

The scientists deciphered, for the first time, the group of microbes that enables a patch of soil to suppress a plant-killing pathogen. Previous research on the phenomenon of disease-suppressive soil had identified one or two pathogen-fighting microbes at work. (more…)

Yale Researchers Identify Four Key Weapons in Immune System’s Arsenal

By Guest PostMay 7, 2011Health4 key weapons, bacterial infections, deliver antimicrobial enzymes, food-borne bacteria, gastrointestinal illness, gtpases, hepatitis c, immune-compromised, interferon therapy, john d. macmicking, macrophage, marshal immune system, microbial pathogenesis, mimic, noxious chemicals, pathogens, pulmonary diseases, tuberculosis, variety of pathogens, winchester fund and cancer research institute, yale university

Yale University researchers have identified four unique host defense proteins among thousands that seem to play a crucial role in mobilizing the immune system’s response to bacterial infections, they report in the May 6 issue of the journal Science.

The findings suggest it may be possible to find new ways to assist immune-compromised patients to fight off a variety of pathogens, the authors say.

“We can start to think about how to mimic these chemical processes and deliver them in drug form,” said John D. MacMicking, associate professor of microbial pathogenesis at Yale School of Medicine and senior author the study. (more…)

Berkeley Lab Scientists Find That Normal Breast Cells Help Kill Cancer Cells

By Guest PostApril 20, 20111 commentHealth, Scienceberkeley lab, breast cancer cells, cytostatic, cytotoxic, dna mutations, extracellular matrix culture, healthy cells, human body, il25, immune system, inflammation, interleukin 25, malignant phenotype, mammary epithelial cells, microenvironmental factors, mina bissell, natural defense mechanism against cancer, pathogens, protein, saori furuta, treatment of breast cancer, tumor cells, tumor surveillance system

It is well known that the human body has a highly developed immune system to detect and destroy invading pathogens and tumor cells. Now, researchers at the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) have shown that the body has a second line of defense against cancer – healthy cells. A new study shows that normal mammary epithelial cells, as they are developing, secrete interleukin 25, a protein known for its role in the immune system’s response to inflammation, for the express purpose of killing nearby breast cancer cells.

“We found that normal breast cells provide an innate defense mechanism against cancer by producing interleukin 25 (IL25) to actively and specifically kill breast cancer cells,” says breast cancer authority Mina Bissell, of Berkeley Lab’s Life Sciences Division, who led this research. “This suggests that IL25 receptor signaling may provide a new therapeutic target for the treatment of breast cancer.” (more…)

Biodiversity Loss: Detrimental to Your Health

By Guest PostDecember 4, 2010Environment, Healthanimal extinctions, biodiversity, disease emergence, ecologist, ecosystems, felicia keesing, forests, global biodiversity, hantavirus, Health, infectious diseases, josh rosenthal, lyme disease, pathogens, plant, sam scheiner, species loss, transmission, west nile virus, wildlife

*Infectious diseases on the rise as species disappear*

Plant and animal extinctions are detrimental to your health.

That’s the conclusion of a paper published in this week’s issue of the journal Nature by scientists who studied the link between biodiversity and infectious diseases. (more…)

How Pathogens Hijack Host Plants

By Guest PostNovember 27, 20101 commentSciencearabidopsis, bacteria, cell membrane, cells, diabetes, fluorescence resonance energy transfer, frank white, fret, fungi, global crop, infestation, li-qing chen, mustard, mutation, novel transporters, organism, pathogen infection, pathogenic bacteria, pathogens, plant nutrients, pore proteins, protein genes, sensor-based technology, sugar efflux, sugar-pumping mechanism, sweets

Palo Alto, CA — Infestation by bacteria and other pathogens result in global crop losses of over $500 billion annually. A research team led by the Carnegie Institution’s Department of Plant Biology developed a novel trick for identifying how pathogens hijack plant nutrients to take over the organism. They discovered a novel family of pores that transport sugar out of the plant. Bacteria and fungi hijack the pores to access the plant sugar for food. The first goal of any pathogen is to access the host’s food supply to allow them to reproduce in large numbers. This is the first time scientists have a direct handle on controlling the food supply to pathogens and thus a new means to prevent a wide range of crop diseases and losses. (more…)

X-Ray Diffraction May Play Key Role in Stopping ‘Kissing Bug,’ Fungus

By Guest PostOctober 22, 2010Health, Scienceaspergillus fumigates, blood-sucking insect, chagas parasite, crime scenes, cure, dale karr, drugs, enzyme, fungus, john tanner, kissing bug, organisms, pablo sobrado, parasite, pathogens, pulmonary diseases, south america, sugar molecule, virginia tech, x ray diffraction

John Tanner, who also teaches chemistry in the College of Arts and Science, is studying Aspergillus fumigatus. Image credit: University of Missouri

COLUMBIA, Mo. – If finding the cure for a fungus and parasite that affects millions of people were the subject of a detective show, University of Missouri Chemistry Professor John Tanner would be the forensic expert in the lab, using high-tech equipment to make a model that could eventually solve the crime.

Tanner, who also teaches chemistry in the College of Arts and Science, has joined forces with Pablo Sobrado, an assistant professor of biochemistry at Virginia Tech, to study a unique enzyme found on two “crime scenes”: in Aspergillus fumigatus, a fungus that causes pulmonary diseases in immuno-compromised people; and in a blood-sucking insect prevalent in South America and now being found in the southwestern U.S., called the Chagas parasite, also known as the “kissing bug” for the red welts left on the victims’ faces after being bitten in his or her sleep.

“My job is to figure out what the enzyme looks like using X-ray diffraction,” Tanner said. “This enzyme makes a special sugar molecule that these organisms need to survive, so if we can find a way to stop the reaction that makes that sugar, then we might find a way to kill these pathogens.” (more…)

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