COLUMBUS, Ohio – Salmonella cells have hijacked the protein-building process to maintain their ability to cause illness, new research suggests.
Scientists say that these bacteria have modified what has long been considered typical cell behavior by using a beta form of an amino acid – as opposed to an alpha form – during the act of making proteins. (more…)
Laminin, long thought to be only a structural support protein in the microenvironment of breast and other epithelial tissue, is “famous” for its cross-like shape. However, laminin is far more than just a support player with a “pretty face.” Two studies led by one of the world’s foremost breast cancer scientists have shown how laminin plays a central role in the development of breast cancer, the second most leading cause of cancer death among women in the United States. In one study it was shown how laminin influences the genetic information inside a cell’s nucleus. In the other study it was shown how destruction of laminin can play a detrimental role in the early stages of tumor development. (more…)
*Molecular “machine” responsible for pulling chromosome copies apart is isolated and seen in action outside the cell*
The dance of cell division is carefully choreographed and has little room for error. Paired genetic information is lined up in the middle of the cell in the form of chromosomes. The chromosomes must then be carefully pulled apart so that the resulting daughter cells each have an identical copy of the mother cell’s DNA. (more…)
*University of Missouri investigators’ discovery sheds light on how plants fight off bacterial infections*
Columbia, MO — Like us, plants rely on an immune system to fight off disease. Proteins that scout out malicious bacterial invaders in the cell and communicate their presence to the nucleus are important weapons in the plant’s disease resistance strategy. Researchers at the University of Missouri recently “tapped” into two proteins’ communications with the nucleus and discovered a previously unknown level of cross talk. The discovery adds important new information about how plant proteins mediate resistance to bacteria that cause disease and may ultimately lead to novel strategies for boosting a plant’s immune system.
Special proteins in the plant, called resistance proteins, can recognize highly specific features of proteins from pathogen, called effector proteins. When a pathogen is detected, a resistance protein triggers an “alarm” that communicates the danger to the cell’s nucleus. The communication between the resistance protein and nucleus occurs through a mechanism called a signaling pathway. (more…)
*Study recognized for significance and importance in the world’s most common genetic disease*
COLUMBIA, Mo. – A University of Missouri researcher believes his latest work moves scientists closer to a cure for 
cystic fibrosis, one of the world’s most common fatal genetic diseases. (more…)
