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Study of the machinery of cells reveals clues to neurological disorder

By Guest PostMay 16, 2013Sciencebiogenesis, cell, charcot, common neurological disorder, crop plants, cross talk, disease causing mutations, embo reports, energy factories, eth zurich, fatty acids, fragmentation of mitochondria, function, humans, kate mcintosh, marie, metabolism, michael schrader, mitochondria, organelles, organelles peroxisomes, peroxisomal division, peroxisomes, reactive oxygen species, researcher, sofia guimaraes, symptoms, tooth disease, touch sensation, uk, university of exeter, yeast

Investigation by researchers from the University of Exeter and ETH Zurich has shed new light on a protein which is linked to a common neurological disorder called Charcot-Marie-Tooth disease.

The team has discovered that a protein previously identified on mitochondria – the energy factories of the cell – is also found on the fat-metabolising organelles peroxisomes, suggesting a closer link between the two organelles.

Charcot-Marie-Tooth disease is currently incurable and affects around one in every 2,500 people in the UK, meaning that it is one of the most common inherited neurological disorders, thus understanding the molecular basis of the disease is of great importance. Symptoms can range from tremors and loss of touch sensation in the feet and legs to difficulties with breathing, swallowing, speaking, hearing and vision. (more…)

Change in Temperature Uncovers Genetic Cross Talk in Plant Immunity

By Guest PostNovember 17, 2010Nature, Sciencearabidopsis thaliana, avrrps4, bacterial infection, bacterial invaders, bacterial pathogen, cell, cross talk, disease, effector proteins, immune system, mechanism, pathogen, plant proteins, plants, proteins, pseudomonas syringae, resistance proteins, saikat bhattacharjee, sang hee kim, srfr1, walter gassmann

*University of Missouri investigators’ discovery sheds light on how plants fight off bacterial infections*

Columbia, MO — Like us, plants rely on an immune system to fight off disease. Proteins that scout out malicious bacterial invaders in the cell and communicate their presence to the nucleus are important weapons in the plant’s disease resistance strategy. Researchers at the University of Missouri recently “tapped” into two proteins’ communications with the nucleus and discovered a previously unknown level of cross talk. The discovery adds important new information about how plant proteins mediate resistance to bacteria that cause disease and may ultimately lead to novel strategies for boosting a plant’s immune system.

Special proteins in the plant, called resistance proteins, can recognize highly specific features of proteins from pathogen, called effector proteins. When a pathogen is detected, a resistance protein triggers an “alarm” that communicates the danger to the cell’s nucleus. The communication between the resistance protein and nucleus occurs through a mechanism called a signaling pathway. (more…)

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Study of the machinery of cells reveals clues to neurological disorder

Change in Temperature Uncovers Genetic Cross Talk in Plant Immunity