Tag Archives: brain pathology

UCLA Study First to Image Concussion-Related Abnormal Brain Proteins in Retired NFL Players

By Guest PostJanuary 24, 2013Healthabnormal gait, abnormal tau proteins, alzheimer's disease, american journal, amyloid beta plaques, athletes, autopsy, body mass index, brain imaging tool, brain injury, brain pathology, centers, chemical marker, chronic traumatic encephalopathy, clinical assessment, cognitive, cognitive ability, confusion, cte, degenerative condition, degree of depression, dementia, depression, disease control, early detection, early symptoms, family history, fddnp, fran, gary small, gauge, geriatric psychiatry, hallmarks of alzheimers, ham d, hamilton rating scale, intravenous injections, jorge r barrio, julian bailes, linda m ercoli, memory loss, mental state examination, mild, mini, mmse, mood symptoms, national football league, neurofibrillary tau tangles, personality changes, PET, player, positron emission tomography, prabha siddarth, prevention, progression in cte, progressive dementia, protein, ray stark foundation, repair damage, risk, sports related concussions, suicidal behavior, traumatic brain injuries, traumatic brain injury, tremors, vladimir kepe, wayne clark

Technique may lead to earlier diagnosis, tracking of brain disorders in athletes

Sports-related concussions and mild traumatic brain injuries have grabbed headlines in recent months, as the long-term damage they can cause becomes increasingly evident among both current and former athletes. The Centers for Disease Control and Prevention estimates that millions of these injuries occur each year.

Despite the devastating consequences of traumatic brain injury and the large number of athletes playing contact sports who are at risk, no method has been developed for early detection or tracking of the brain pathology associated with these injuries. (more…)

Researchers Report Potential New Treatment to Stop Alzheimer’s Disease

By Guest PostNovember 16, 2012Health, Sciencealzheimer, amyloid beta, blood brain barrier, brain, brain pathology, cell, clr01, disease, disorders, gal bitan, inhibitor, mammalian animal model, memory, molecular compound, molecular tweezer, mouse model, neuron, parkinsons disease, pathologic feature, process specific, radioactive label, tau, toxic protein, ucla

Molecular ‘tweezers’ break up toxic aggregations of proteins in mouse model

Last March, researchers at UCLA reported the development of a molecular compound called CLR01 that prevented toxic proteins associated with Parkinson’s disease from binding together and killing the brain’s neurons.

Building on those findings, they have now turned their attention to Alzheimer’s disease, which is thought to be caused by a similar toxic aggregation or clumping, but with different proteins, especially amyloid-beta and tau. (more…)