Structural model of physiological tau-microtubule interactions sheds light on neurological diseases that correlate with their disruption
Researchers at Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California, Berkeley have combined cutting-edge cryo-electron microscopy (cryo-EM) with computational molecular modeling to produce a near-atomic-resolution model of the interaction between microtubules – crucial components of eukaryotic cell ultrastructure – and microtubule-associated proteins called tau.(more…)
Daya Bay neutrino experiment releases high-precision measurement of subatomic shape shifting and new result on differences among neutrino masses
The international Daya Bay Collaboration has announced new results about the transformations of neutrinos – elusive, ghostlike particles that carry invaluable clues about the makeup of the early universe. The latest findings include the collaboration’s first data on how neutrino oscillation – in which neutrinos mix and change into other “flavors,” or types, as they travel – varies with neutrino energy, allowing the measurement of a key difference in neutrino masses known as mass splitting.
“Understanding the subtle details of neutrino oscillations and other properties of these shape-shifting particles may help resolve some of the deepest mysteries of our universe,” said Jim Siegrist, Associate Director of Science for High Energy Physics at the U.S. Department of Energy (DOE), the primary funder of U.S. participation in Daya Bay. (more…)
Molecular ‘tweezers’ break up toxic aggregations of proteins in mouse model
Last March, researchers at UCLA reported the development of a molecular compound called CLR01 that prevented toxic proteins associated with Parkinson’s disease from binding together and killing the brain’s neurons.
Building on those findings, they have now turned their attention to Alzheimer’s disease, which is thought to be caused by a similar toxic aggregation or clumping, but with different proteins, especially amyloid-beta and tau. (more…)
