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Researchers Report Potential New Treatment to Stop Alzheimer’s Disease

Molecular ‘tweezers’ break up toxic aggregations of proteins in mouse model

Last March, researchers at UCLA reported the development of a molecular compound called CLR01 that prevented toxic proteins associated with Parkinson’s disease from binding together and killing the brain’s neurons.

Building on those findings, they have now turned their attention to Alzheimer’s disease, which is thought to be caused by a similar toxic aggregation or clumping, but with different proteins, especially amyloid-beta and tau. (more…)

U of T Researcher Discovers Way to Zip Away Chronic Pain

By Guest PostDecember 6, 20101 commentHealth, Scienceacc, anterior cingulate cortex, bong-kiun kaang, chronic pain, forebrain, graham collingridge, inhibitor, min zhuo, nerve injury, peptide, pkmζ, plastic changes, protein kinase m zeta, psychogenic pain, zip, ζ-pseudosubstrate

*Peptide inhibitor called ZIP may be instrumental*

Research from the University of Toronto suggests that a peptide inhibitor called ZIP could be crucial in zipping away some kinds of chronic pain.

The new research, led by Professor Min Zhuo of the University of Toronto’s Department of Physiology and published in the current edition of the journal Science, explores the role that the protein kinase M zeta (PKMζ) plays in storing “memories” of pain and therefore enhancing the sensation of pain. Blocking the effect of PKMζ through the use of a selective inhibitor called ζ-pseudosubstrate inhibitory peptide – or ZIP — blocked behavioral sensitization and nerve injury related to chronic pain. (more…)

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Researchers Report Potential New Treatment to Stop Alzheimer’s Disease

U of T Researcher Discovers Way to Zip Away Chronic Pain