Tag Archives: DNA

UA Scientists Help Discover Most Abundant Ocean Virus

By Guest PostFebruary 14, 2013Scienceabundant ocean virus, biogeochemical cycle, bonnie hurwitz, carbon, carbon cycle, carbon dioxide, cellular biology, DNA, global cycle, human genome researcher, j craig venter, marine, marine bacterium sar11, matthew sullivan, methods, molecular, most abundant organism, old fashioned research, oregon state university, oxygen, pelagiphages, phage research lab, planet, sar11 bacteria, stephen giovannoni, tucson, university of arizona, viral diversity, viral infection

Researchers have discovered four previously unknown viruses that infect the Earth’s most abundant organism, the marine bacterium SAR11. Because of their huge numbers, these tiny players have critical roles in the global cycle of carbon and other nutrients.

The greatest battle in Earth’s history has been going on for hundreds of millions of years, isn’t over yet, and until now no one knew it existed, scientists reported today in the journal Nature.

In one corner is the Earth’s most abundant organism: SAR11, an ocean-living bacterium that survives where most other cells would die and plays a major role in the planet’s carbon cycle. It had been theorized that SAR11 was so small and widespread that it must be invulnerable to attack. (more…)

A Boost for Analyzing Biological Sequences

By Guest PostFebruary 10, 2013Scienceanalyzing sequence data, best parameters, biological molecules, biologists, computational biologists, computational model, dan deblasio, detect, DNA, evolutionary past, guessing game, improved software, john kececioglu, model, parameter advising, parameter values, parameters, phenomena, predict missing data, proteins, run alignment software, software tools, species, ua computer scientists, university of arizona

UA computer scientists John Kececioglu and Dan DeBlasio are developing improved software that provides biologists with much more accurate results when analyzing sequence data.

Imagine trying to construct a brick building with fewer than the requisite number of bricks and without a detailed blueprint.

Welcome to the world of computational biologists.

When biologists study proteins, DNA, or other biological molecules that are represented in the computer as sequences, they rely on known information but also must predict missing data. Given that reality, major challenges exist to having accurate results. (more…)

Aging Cells Lose Their Grip on DNA Rogues

By Guest PostFebruary 3, 2013Scienceabigail peterson, aging bodies, aging cells, balls of protein, barbara mcclintock, brown university, chromatin, chromosomes, computational biologist, desirable genes, DNA, edward peckham, eliza hamm, enzyme, essential genes, euchromatin formations, faire, genetic material, genome, genomic havoc, heterochromatin, heterochromatin prison system, high stakes warfare, hiv drugs, human fibroblast cells, human retrotransposons, jayameenakshi manivannan, jill kreiling, john sedivy, l1, marco de cecco, mobile strands, molecular parasites, nicola neretti, nobel prize, nucleosomes, parasitic strands, reverse transcriptases, rna, sara hillenmeyer, senescent, senescent cells, steven criscione, technique, transposable elements, transposons, transposons in maize, useful genes

Transposable elements are mobile strands of DNA that insert themselves into chromosomes with mostly harmful consequences. Cells try to keep them locked down, but in a new study, Brown University researchers report that aging cells lose their ability to maintain this control. The result may be a further decline in the health of senescent cells and of the aging bodies they compose.

PROVIDENCE, R.I. [Brown University] — Even in our DNA there is no refuge from rogues that prey on the elderly. Parasitic strands of genetic material called transposable elements — transposons — lurk in our chromosomes, poised to wreak genomic havoc. Cells have evolved ways to defend themselves, but in a new study, Brown University researchers describe how cells lose this ability as they age, possibly resulting in a decline in their function and health. (more…)

Genes and obesity: Fast food isn’t only culprit in expanding waistlines — DNA is also to blame

By Guest PostJanuary 19, 2013Healthadipose, bmi, body fat response, body mass index, brian parks, cancer, control, degree of obesity, diverse mouse population, DNA, elin org, elizabeth nam, emrah kostem, environmental conditions, environmental factors, epidemic, fast food diet, fat, fat tissue, frode norheim, genetic factor, genetics, global gene expression, heart disease, high calorie diets, inbred strains, intestinal bacteria, intestinal flora, jake lusis, level, metabolic response, mice, modeling, obesity traits, sedentary lifestyles, strains, sugar, type 2 diabetes, ucla, weight gain

Researchers at UCLA say it’s not just what you eat that makes those pants tighter — it’s also genetics. In a new study, scientists discovered that body-fat responses to a typical fast-food diet are determined in large part by genetic factors, and they have identified several genes they say may control those responses.

The study is the first of its kind to detail metabolic responses to a high-fat, high-sugar diet in a large and diverse mouse population under defined environmental conditions, modeling closely what is likely to occur in human populations. The researchers found that the amount of food consumed contributed only modestly to the degree of obesity. (more…)

Plumes across the Pacific Deliver Thousands of Microbial Species to West Coast

By Guest PostDecember 20, 2012Environmentaerobiology, aerosol, air pollution, aircraft, asia, atmospheric particle, bacterial, balloons, biomass, cascade mountains, central oregon, dale griffin, daniel jaffe, david j smith, dilution, DNA, dust, dust plume, earth, ecosystem, fungal, global wind circulation, harmless, hilkka timonen, kevin perry, michael roberts, michele birmele, microorganism, molecular method, mount bachelor, NASA, North America, old classification, pacific ocean, peter ward, plume event, pollutant, traditional paradigm, trans pacific trip, troposphere, university of utah, university of washington, west coast

A surprising number of microorganisms – more than 100 times more kinds than reported just four months ago – are leaping the biggest gap on the planet. Hitching rides in the upper troposphere, they’re making their way from Asia across the Pacific Ocean and landing in North America.

For the first time researchers have been able to gather enough biomass in the form of DNA to apply molecular methods to samples from two large dust plumes originating in Asia in the spring of 2011. The scientists detected more than 2,100 unique species compared to only 18 found in the very same plumes using traditional methods of culturing, results they published in July. (more…)

Space Life

By Guest PostDecember 7, 2012Scienceask magazine, astrobiology, biology, c elegans, chandran sabanayagam, cubesat projects, dbi, desg, DNA, does life exist, earth, Environment, evolution, microbes, microscopic worms, NASA, physicist, proteins, space life, space research, telemetry, trl3, universe, zero gravity

NASA funds astrobiology research by Delaware Biotechnology Institute scientist

Does life exist anywhere else in the universe? That’s the type of broad but poignant question NASA likes to ask, according to Chandran Sabanayagam, associate scientist in the Bioimaging Center at the Delaware Biotechnology Institute (DBI). And he would know, because he’s preparing to help answer it.

NASA will receive $100 billion from the federal government over the next five years to assure America is number one in space exploration, according to Astrobiology.com. As part of its push to seek new partnerships and broaden its vision, NASA is offering grants to people conducting transformational science. With this opportunity, Sabanayagam is merging his love of physics and biology. (more…)

Berkeley Lab Scientists Help Develop Promising Therapy for Huntington’s Disease

By Guest PostNovember 11, 2012Healthalzheimers, antidepressants, bacterial membrane, berkeley lab, cells, cerebral cortex, chemist, coenzyme q, cognitive decline, compound, cynthia mcmurray, DNA, genetic disorder, genetic mutation, huntingtons disease, loss, mice, mitochondria, mitochondrial function, molecules, motor coordination, motor skills, muscle coordination, neurodegenerative diseases, neuron, organelle, oxidative damage, parkinson's, peter wipf, pittsburgh, power plant, reactive oxygen species, striatum, suppress, survival, symptoms, synthetic antioxidant, university, untreated neuronal cultures, vitamin e, xjb 5 131, xjb treated mice, zhiyin xun

Initial results in mice could lead to new way to fight neurodegenerative diseases

There’s new hope in the fight against Huntington’s disease. A group of researchers that includes scientists from the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) have designed a compound that suppresses symptoms of the devastating disease in mice.

The compound is a synthetic antioxidant that targets mitochondria, an organelle within cells that serves as a cell’s power plant. Oxidative damage to mitochondria is implicated in many neurodegenerative diseases including Alzheimer’s, Parkinson’s, and Huntington’s. (more…)

PTSD Consortium

By Guest PostNovember 1, 2012Healthadult, afghanistan, americans, bad experience, behavior, behavioral epigenetic, brain, brain imaging, cambridge, car accident, cardiovascular disease, chemical change, combat troops, david diamond, delaware, diagnose, disorder, DNA, dna methylation, draper laboratory, gene, hormone level, Iraq, military, molecular change, molecular modification, objective biomarker, panic attack, posttraumatic, ptsd, rate, rodent model, south florida, stress, stress disorder, tania roth, trauma, university, victim, violent crime, war

Researchers seek better ways to diagnose, treat disorder

Tania Roth studies what happens to the brain when stress occurs early in life, seeking to pinpoint how those kinds of bad experiences can cause molecular changes to DNA.

Now, by participating in a national consortium of researchers, the assistant professor of psychology at the University of Delaware is hoping to use her expertise to contribute to a better understanding of posttraumatic stress disorder (PTSD). (more…)