non coding – Shamskm: A site to exchange knowledge and solutions

A Welcome Predictability

By Guest PostOctober 9, 2012Scienceadam arkin, adaptor, advanced phase, bacteria, bacterial, berkeley lab, carbon, cell, chang liu, code, composability, computer hardware, criteria, denise wang, dna nucleotides, element, energy fuel, Environment, escherichia coli, fluorescence microscopy, function, gene, genetic engineering, global cycle, higher order, image, julius lucks, lei qi, medical drug, microbial component, molecules, non coding, plasmid pair, radioactive waste, rna, sustainable production, synthesize protein, synthetic biology, synthetic circuit, thomas segall shapiro, toxic, transcriptional elongation, translational regulator, utrs, vivek mutalik

Berkeley Lab Researchers Develop New Tool for Making Genetic Engineering of Microbial Circuits Reliably Predictable

Synthetic biology is the latest and most advanced phase of genetic engineering, holding great promise for helping to solve some of the world’s most intractable problems, including the sustainable production of energy fuels and critical medical drugs, and the safe removal of toxic and radioactive waste from the environment. However, for synthetic biology to reach its promise, the design and construction of biological systems must be as predictable as the assembly of computer hardware.

An important step towards attaining a higher degree of predictability in synthetic biology has been taken by a group of researchers with the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) under the leadership of computational biologist Adam Arkin. Arkin and his team have developed an “adaptor” that makes the genetic engineering of microbial components substantially easier and more predictable by converting regulators of translation into regulators of transcription in Escherichia coli. Transcription and translation make up the two-step process by which the coded instructions of genes are used to synthesize proteins. (more…)

Yale Team Finds Order Amidst the Chaos Within the Human Genome; Mom and Dad’s Contributions Counted and Fossil DNA Not Dead After All

The Encyclopedia of DNA Elements (ENCODE) project is the effort of hundreds of scientists to describe the workings of the human genome. Their research, outlined in 30 papers published in multiple journals Sept. 5, has confirmed our genome is far more complex than originally thought. Regions that contain instructions for making proteins, which carry out life’s functions, account for only about 1 percent of our genome. ENCODE has shed light on the other 99%. Almost 80 percent of the genome is biochemically active, much of it involved in some sort of regulation of genes. Vast regions of our DNA once considered “junk” contain some 400,000 regulators called enhancers, which play a key role activating or silencing genes despite residing far away from the gene itself. Yale University researchers played a key role ENCODE, helping to author 9 of the 30 papers published in four journals on Sept. 5. Some of their work is described below.

The massive Encyclopedia of DNA Elements (ENCODE) unveiled Sept. 5 reveals a human genome vastly more rich and complex than envisioned even a decade ago. In a key supporting paper published in the journal Nature, the lab of Yale’s Mark Gerstein, the Albert L. Williams Professor of Biomedical Informatics, has found order amidst the seeming chaos of trillions of potential molecular interactions. (more…)

Tag Archives: non coding

A Welcome Predictability

Yale Team Finds Order Amidst the Chaos Within the Human Genome; Mom and Dad’s Contributions Counted and Fossil DNA Not Dead After All