Tag Archives: DNA

A ‘Golden Era’ of Insight: Big Data’s Bright Future

By Guest PostFebruary 18, 2013Technologybangalore, Beijing, big data, bing, bing directions, bing maps, bing voice search, biomedical informatics terabytes, breakthroughs, bright future, buzzwords, cambridge, capturing data, China, computational mechanisms, data analytics, data centric methods, decision-making, distinguished scientist, DNA, eric horvitz, golden era, government, hawaii, insight, labs, law, machine intelligence, machine learning, mandarin, microsoft research, networking, new england, new york city, North America, predictive modeling, predictive models, redmond, rick rashid, sensing, silicon valley, storage, tianjin, traffic free route, visualization, web

For over 20 years, Microsoft Research’s labs around the world have focused on research across a broad spectrum of topics in computer science. From the start, the organization has invested heavily in pioneering breakthroughs in machine intelligence, including efforts in machine learning and big data. In this interview, Distinguished Scientist Eric Horvitz talks about advances he sees on the horizon, the influence they will have on your daily life, and how insights from big data and developing more intelligent software and services will change the world.

REDMOND, Wash. – Feb. 15, 2013 – At Microsoft Research labs around the world, some very deep thinkers are contemplating big data.

This includes Eric Horvitz, distinguished scientist at Microsoft and co-director of Microsoft Research’s Redmond lab, who was recently elected to the National Academy of Engineering for his work in “computational mechanisms for decision making under uncertainty and with bounded resources.” (more…)

A Boost for Analyzing Biological Sequences

By Guest PostFebruary 10, 2013Scienceanalyzing sequence data, best parameters, biological molecules, biologists, computational biologists, computational model, dan deblasio, detect, DNA, evolutionary past, guessing game, improved software, john kececioglu, model, parameter advising, parameter values, parameters, phenomena, predict missing data, proteins, run alignment software, software tools, species, ua computer scientists, university of arizona

UA computer scientists John Kececioglu and Dan DeBlasio are developing improved software that provides biologists with much more accurate results when analyzing sequence data.

Imagine trying to construct a brick building with fewer than the requisite number of bricks and without a detailed blueprint.

Welcome to the world of computational biologists.

When biologists study proteins, DNA, or other biological molecules that are represented in the computer as sequences, they rely on known information but also must predict missing data. Given that reality, major challenges exist to having accurate results. (more…)

Aging Cells Lose Their Grip on DNA Rogues

By Guest PostFebruary 3, 2013Scienceabigail peterson, aging bodies, aging cells, balls of protein, barbara mcclintock, brown university, chromatin, chromosomes, computational biologist, desirable genes, DNA, edward peckham, eliza hamm, enzyme, essential genes, euchromatin formations, faire, genetic material, genome, genomic havoc, heterochromatin, heterochromatin prison system, high stakes warfare, hiv drugs, human fibroblast cells, human retrotransposons, jayameenakshi manivannan, jill kreiling, john sedivy, l1, marco de cecco, mobile strands, molecular parasites, nicola neretti, nobel prize, nucleosomes, parasitic strands, reverse transcriptases, rna, sara hillenmeyer, senescent, senescent cells, steven criscione, technique, transposable elements, transposons, transposons in maize, useful genes

Transposable elements are mobile strands of DNA that insert themselves into chromosomes with mostly harmful consequences. Cells try to keep them locked down, but in a new study, Brown University researchers report that aging cells lose their ability to maintain this control. The result may be a further decline in the health of senescent cells and of the aging bodies they compose.

PROVIDENCE, R.I. [Brown University] — Even in our DNA there is no refuge from rogues that prey on the elderly. Parasitic strands of genetic material called transposable elements — transposons — lurk in our chromosomes, poised to wreak genomic havoc. Cells have evolved ways to defend themselves, but in a new study, Brown University researchers describe how cells lose this ability as they age, possibly resulting in a decline in their function and health. (more…)

Genes and obesity: Fast food isn’t only culprit in expanding waistlines — DNA is also to blame

By Guest PostJanuary 19, 2013Healthadipose, bmi, body fat response, body mass index, brian parks, cancer, control, degree of obesity, diverse mouse population, DNA, elin org, elizabeth nam, emrah kostem, environmental conditions, environmental factors, epidemic, fast food diet, fat, fat tissue, frode norheim, genetic factor, genetics, global gene expression, heart disease, high calorie diets, inbred strains, intestinal bacteria, intestinal flora, jake lusis, level, metabolic response, mice, modeling, obesity traits, sedentary lifestyles, strains, sugar, type 2 diabetes, ucla, weight gain

Researchers at UCLA say it’s not just what you eat that makes those pants tighter — it’s also genetics. In a new study, scientists discovered that body-fat responses to a typical fast-food diet are determined in large part by genetic factors, and they have identified several genes they say may control those responses.

The study is the first of its kind to detail metabolic responses to a high-fat, high-sugar diet in a large and diverse mouse population under defined environmental conditions, modeling closely what is likely to occur in human populations. The researchers found that the amount of food consumed contributed only modestly to the degree of obesity. (more…)

Space Life

By Guest PostDecember 7, 2012Scienceask magazine, astrobiology, biology, c elegans, chandran sabanayagam, cubesat projects, dbi, desg, DNA, does life exist, earth, Environment, evolution, microbes, microscopic worms, NASA, physicist, proteins, space life, space research, telemetry, trl3, universe, zero gravity

NASA funds astrobiology research by Delaware Biotechnology Institute scientist

Does life exist anywhere else in the universe? That’s the type of broad but poignant question NASA likes to ask, according to Chandran Sabanayagam, associate scientist in the Bioimaging Center at the Delaware Biotechnology Institute (DBI). And he would know, because he’s preparing to help answer it.

NASA will receive $100 billion from the federal government over the next five years to assure America is number one in space exploration, according to Astrobiology.com. As part of its push to seek new partnerships and broaden its vision, NASA is offering grants to people conducting transformational science. With this opportunity, Sabanayagam is merging his love of physics and biology. (more…)

Berkeley Lab Scientists Help Develop Promising Therapy for Huntington’s Disease

By Guest PostNovember 11, 2012Healthalzheimers, antidepressants, bacterial membrane, berkeley lab, cells, cerebral cortex, chemist, coenzyme q, cognitive decline, compound, cynthia mcmurray, DNA, genetic disorder, genetic mutation, huntingtons disease, loss, mice, mitochondria, mitochondrial function, molecules, motor coordination, motor skills, muscle coordination, neurodegenerative diseases, neuron, organelle, oxidative damage, parkinson's, peter wipf, pittsburgh, power plant, reactive oxygen species, striatum, suppress, survival, symptoms, synthetic antioxidant, university, untreated neuronal cultures, vitamin e, xjb 5 131, xjb treated mice, zhiyin xun

Initial results in mice could lead to new way to fight neurodegenerative diseases

There’s new hope in the fight against Huntington’s disease. A group of researchers that includes scientists from the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) have designed a compound that suppresses symptoms of the devastating disease in mice.

The compound is a synthetic antioxidant that targets mitochondria, an organelle within cells that serves as a cell’s power plant. Oxidative damage to mitochondria is implicated in many neurodegenerative diseases including Alzheimer’s, Parkinson’s, and Huntington’s. (more…)

Analysis of Dinosaur Bone Cells Confirms Ancient Protein Preservation

By Guest PostOctober 26, 2012Scienceancient dinosaur, antibodies, backbone, bone cell, brachylophosaurus canadensis, cellular structure, collagen, dinosaurian, DNA, dna molecule, evolutionary change, fibrous material, fibrous matrix, histochemistry, marshall bern, mary schweitzer, mass spectrometry, microbe, microscopy, north Carolina, origin, osteocytes, ostrich osteocytes, palo alto, parc, phex, protein, reactivity, research center, sample contamination, state university, tyrannosaurus rex, vertebrate, wenxia zheng

A team of researchers from North Carolina State University and the Palo Alto Research Center (PARC) has found more evidence for the preservation of ancient dinosaur proteins, including reactivity to antibodies that target specific proteins normally found in bone cells of vertebrates. These results further rule out sample contamination, and help solidify the case for preservation of cells – and possibly DNA – in ancient remains.

Dr. Mary Schweitzer, professor of marine, earth and atmospheric sciences with a joint appointment at the North Carolina Museum of Natural Sciences, first discovered what appeared to be preserved soft tissue in a 67-million-year-old Tyrannosaurus Rex in 2005. Subsequent research revealed similar preservation in an even older (about 80-million-year-old)Brachylophosaurus canadensis. In 2007 and again in 2009, Schweitzer and colleagues used chemical and molecular analyses to confirm that the fibrous material collected from the specimens was collagen. (more…)

Sticky Paper Offers Cheap, Easy Solution for Paper-Based Diagnostics

By Guest PostOctober 4, 2012Scienceacidity, antibodies, arthur yu, biological molecule, chemical trick, daniel ratner, diabetes, diagnostic, disease, divinyl sulfone, DNA, fluorescent ricin, galactose, george whitesides, global, harvard university, health research, immune system, industrial solvent, jing shang, malaria, medical test, nitrocellulose, oldest technology, paper, paper stick, paul yager, plain paper, poison, pregnancy test, protein, rodrigo andrade, sticky membrane, university, Washington, ziploc bag

A current focus in global health research is to make medical tests that are not just cheap, but virtually free. One such strategy is to start with paper – one of humanity’s oldest technologies – and build a device like a home-based pregnancy test that might work for malaria, diabetes or other diseases.

A University of Washington bioengineer recently developed a way to make regular paper stick to medically interesting molecules. The work produced a chemical trick to make paper-based diagnostics using plain paper, the kind found at office supply stores around the world. (more…)